Investigating antibiotic dosing in elderly patients at the emergency department
Antibiotic Dosing in Geriatric Patients At the Emergency Department
This study is testing if the current doses of certain antibiotics work well enough for frail patients aged 75 and older who come to the emergency department.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 75 Years and up |
| Sex | All |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Trial ID | NCT04436991 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to evaluate whether current dosing regimens of beta-lactam antibiotics, specifically Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Temocillin, achieve pharmacodynamic targets in frail patients aged 75 years or older admitted to the geriatric department. The study is observational and involves blood sampling to assess pharmacokinetics and pharmacodynamics in this vulnerable population. By focusing on geriatric patients, the study addresses a significant gap in antibiotic dosing research, as older adults are often excluded from clinical trials. The research is being conducted at the Ghent University Hospital's emergency and geriatric departments.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 75 years or older who are admitted to the geriatric department and are receiving specific beta-lactam antibiotics.
Not a fit: Patients who are admitted to units other than the geriatric department or those with known hypersensitivity to beta-lactam antibiotics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to optimized antibiotic dosing for elderly patients, improving treatment outcomes and reducing the risk of antibiotic resistance.
How similar studies have performed: This approach is novel, as no previous studies have specifically investigated beta-lactam antibiotic dosing in frail geriatric patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting at the emergency department and later on admitted to the geriatric department * Patient age 75 years or older * Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score. * Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam) * Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required. Exclusion Criteria: * Admission to other units than the geriatric department incl. the ICU. * Absence of informed consent * Known hypersensitivity to beta-lactam antibiotics * Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.
Where this trial is running
Ghent
- University Hospital Ghent — Ghent, Belgium (Recruiting)
Study contacts
- Principal investigator: Tania Desmet, Dr. — University Hospital, Ghent
- Study coordinator: Peter De Paepe, Prof. Dr.
- Email: peter.depaepe@uzgent.be
- Phone: 003293325211
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.