Investigating airway closure during ECMO for respiratory failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
This study looks at how to safely use breathing machines with ECMO to help people with severe breathing problems get enough oxygen without hurting their lungs.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 299 (estimated) |
| Sex | All |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT05196074 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with acute hypoxemic respiratory failure who are receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO). It aims to understand the safe use of mechanical ventilation settings in conjunction with ECMO to optimize oxygen delivery while minimizing lung injury. The study will analyze patients who have been cannulated for ECMO within the last 24 hours to gather data on their respiratory management. The findings could provide insights into improving care for critically ill patients requiring advanced respiratory support.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with acute hypoxemic respiratory failure who are currently on VV-ECMO.
Not a fit: Patients with air leaks, those on VV-ECMO as a bridge to lung transplantation, or those experiencing status asthmaticus may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and lung protection strategies for patients with severe respiratory failure.
How similar studies have performed: While the approach of using ECMO in respiratory failure is established, the specific investigation of airway closure during ECMO is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute hypoxemic respiratory failure * VV-ECMO * Less than 24 hours from ECMO cannulation Exclusion Criteria: * Air leak * VV-ECMO as bridge to lung transplantation * Status asthmaticus
Where this trial is running
Toronto, Ontario
- Toronto General Hospital — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Lorenzo Del Sorbo, MD — University Health Network, Toronto
- Study coordinator: Hesham Abdelhady, B Pharm
- Email: Hesham.Abdelhady@uhn.ca
- Phone: 416-340-4800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.