Investigating AION-301 for Chronic Kidney Disease

A Double-blinded, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of AION-301 Administered by Intravenous Infusion for the Treatment of Participants With Stage 3 Chronic Kidney Disease

This study is testing a new treatment called AION-301 to see if it can help adults with Stage 3 Chronic Kidney Disease feel better and manage their symptoms.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 36 (estimated)
• Ages: 35 Years to 75 Years
• Sex: All
• Sponsor: AION Healthspan, Inc. (Industry-sponsored)
• Locations: 2 sites (Miami, Florida and 1 other locations)
• Trial ID: NCT06721143 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the safety, tolerability, and preliminary efficacy of AION-301 administered via intravenous infusion in adults aged 35 to 75 with Stage 3 Chronic Kidney Disease (CKD). Participants will receive two infusions of AION-301 or a placebo on separate days, along with oral vitamins for 90 days. The study will monitor adverse events and assess improvements in CKD symptoms over a period of up to 24 months through regular clinic visits and tests.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 35 to 75 with a diagnosis of Stage 3 Chronic Kidney Disease.

Not a fit: Patients with CKD stages other than Stage 3 or those outside the age range of 35 to 75 may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could potentially slow the progression of Chronic Kidney Disease and improve patient symptoms.

How similar studies have performed: While there have been studies on CKD treatments, the specific approach using AION-301 is novel and has not been extensively tested in this context.

Eligibility criteria

Inclusion Criteria:

Participants are eligible to be included in the study only if all of the following criteria apply:

* Patient is able to communicate well with the investigator, is capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol, understands all requirements of the study, and understands and signs the written ICF before any study-specific procedure.
* Willing and able to comply with the scheduled visits and treatment plan.
* Either biological sex
* Participant must be 35 to 75 years of age inclusive, at the time of signing the informed consent.
* Diagnosis of CKD stage 3, G3 (a and b): persistent eGFR between 30 and 59 mL/min/1.73 m² (at least 2 measures within that range in the preceding 3 months, including the one at screening visit), and persistent increased Albuminuria (at least 2 measures within 3 months, including 1 before screening and 1 at screening (criterion for increased Albuminuria at screening: ≥2 out of 3 repeat daily early morning samples at screening) (UACR ≥ 200 mg/g and \< than 5000 mg/g)
* Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), and SGLT2 inhibitors (SGLT2i) unless such treatment is contraindicated or not tolerated\*. Treatment dose must be stable for at least 3 months prior to the date of the screening. If a patient is on treatment with GLP-1 receptor agonist, he/she should be on a stable dose for at least 3 months before screening.

  \*Participants who are documented to be unable to take ACE inhibitors or ARBs or SGLT2i will be allowed to participate.
* Female subjects must not be breastfeeding and must have no intention to become pregnant during the study, and she will be required to use at least two FDA approved birth control during the study. The FDA-approved and cleared methods for birth control are listed below:

  * Permanent Sterilization
  * Long-Acting Reversible Contraceptives (LARC)
  * Contraceptive Injection
  * Short-Acting Hormonal Methods
  * Barrier Methods
  * Emergency Contraception
* Any male subject must agree to use contraceptives and not donate sperm during the study.
* Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

Exclusion Criteria:

Participants are excluded from the study if any of the following criteria apply:

* Prior transplant of any organ (including BM and stem cell transplant) or kidney transplant scheduled in the next 6 months.
* Proteinuria\>5000 and or serum Albumin\< 2.5 g/dl.
* Acute coronary syndrome, stroke or TIA or hospitalization for heart failure in previous 12 weeks or poorly controlled hypertension (≥160/100 mmHg at screening visit) or SBP\<90 at screening visit.
* History of malignancy (except successfully treated squamous and basal cells skin carcinoma) within 5 years of screening.
* History of atrial fibrillation (AF, AFib).
* CKD due to genetic disorder.
* History of systemic Autoimmune diseases like T1D, SLE or CKD caused by any autoimmune kidney disease.
* Acute Kidney Injury (AKI) defined as increase in serum creatinine ≥1.5 times baseline in the previous 3 months or by presence of acute tubular injury in kidney biopsy in the previous 3 months.
* Dialysis for acute renal failure within 12 weeks of screening visit.
* Rapidly progressive kidney disease (eGFR reduction ≥ 30% over the last three months)
* HbA1c ≥ 8.5%.
* BMI ≥35 kg/m2.
* Disorder of coagulation (including any history of thrombotic or thromboembolic disease) and/or long-term anti-coagulant therapy
* History of Deep Vein Thrombosis (DVT)
* History of Acute Pulmonary Embolism
* History of solitary kidney.
* On medications such as immunosuppressant, monoclonal antibodies, anabolic steroids, at the time of screening or in the previous 6 months and/or illicit drugs.
* History of alcohol abuse or cigarette smoking in the previous 6 months.
* Pregnancy or breast feeding at the time of screening, or with intention to become pregnant or breast-feeding during the course of the study, including the follow-up period.
* History of liver disease, ALT and AST ≥3 x ULN, positive serology for Hepatitis B or Hepatitis C, HIV.
* A significant medical history or abnormality at the physical exam that, in the judgment of the principal investigator, may interfere with the study.
* Presence of any active infection, including COVID 19
* Any clinically significant pulmonary disease
* History of hypersensitivity to study drug and/or any of its excipients.
* Close affiliation with the investigational site; for example, a close relative of the investigator, dependent person (for example employee or student of the investigational site).
* Panel Reactive Antibodies (PRA) \>0% (positive)

Where this trial is running

Miami, Florida and 1 other locations

• SouthCoast Research Center, Inc. — Miami, Florida, United States (Recruiting)
• University of Miami, Leonard M. Miller School of Medicine — Miami, Florida, United States (Recruiting)

Study contacts

• Study coordinator: Giacomo Lanzoni, PHD

Conditions Chronic Kidney Disease Stage 3; CKD; AION-301; Stage 3 CKD; Chronic Kidney Disease