Investigating a new treatment for knee osteoarthritis

A Double-blind, Placebo Controlled First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intra-articular Doses of SAR446959, in Participants With Osteoarthritis of the Knee

This study is testing a new drug for knee osteoarthritis to see if it's safe and well-tolerated in people aged 45 to 65.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 32 (estimated)
• Ages: 45 Years to 65 Years
• Sex: All
• Sponsor: Sanofi (Industry-sponsored)
• Locations: 1 site (Berlin)
• Trial ID: NCT06704932 on ClinicalTrials.gov

What this trial studies

This is a Phase 1, randomized, placebo-controlled study designed to evaluate the safety and tolerability of SAR446959, an investigational drug, in participants aged 45 to 65 with knee osteoarthritis. Participants will receive either the drug or a placebo through a single intra-articular injection, followed by a series of assessments over approximately 28 weeks. The study will include multiple visits for monitoring pharmacokinetics and pharmacodynamics, as well as safety evaluations.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 45 to 65 with a diagnosis of primary knee osteoarthritis and specific symptom criteria.

Not a fit: Patients with severe osteoarthritis (Kellgren-Lawrence grade 4) or those with other significant health issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for managing knee osteoarthritis symptoms.

How similar studies have performed: While this approach is novel, similar studies targeting osteoarthritis treatments have shown promise in the past.

Eligibility criteria

Inclusion Criteria: Participants must have a diagnosis of primary knee osteoarthritis, based on the American College of Rheumatology Clinical criteria using history and physical examination in the index knee

* Participants must have index knee OA symptoms since at least 6 months before screening.
* Participant must have a Kellgren-Lawrence grade of 1-3 in the tibio-femoral compartment in the index knee confirmed by radiography in standing weight-bearing fixed flexion position and posterior-anterior view at screening or within 6 months before screening.
* Participant must have a KOOS Pain subscale score of at least 25 and a maximum of 75 (on 0-100 score) at screening.

Vital signs after 10 minutes resting in supine position at screening within the following ranges:

* 95 mmHg \<systolic blood pressure (SBP) \<140 mmHg
* 45 mmHg \<diastolic blood pressure (DBP) \<90 mmHg
* 50 bpm \<heart rate (HR) \<100 bpm

  * Standard 12-lead electrocardiogram (ECG) parameters after 10 minutes resting in supine position at screening in the following ranges; 120 ms\<PR\<220 ms, 50 bpm \<heart rate (HR) \<100 bpm; QRS\<120 ms, QTcF (Fridericia algorithm recommended) ≤450 ms and normal ECG tracing unless the Investigator considers an ECG tracing abnormality to be not clinically relevant.
  * At Screening and Day- 1, laboratory parameters within the normal range (or defined screening threshold for the Investigator site), unless the Investigator considers an abnormality to be clinically irrelevant for the participant. Hepatic transaminases (aspartate aminotransferase, alanine aminotransferase) should not exceed 1.5 × the upper laboratory normal. Total bilirubin value up to 1.5-fold the upper normal limit can be acceptable if associated with normal conjugated bilirubin value (unless the participant has documented Gilbert syndrome).
  * Participant must have a body mass index (BMI) \<35 kg/m2.

Exclusion Criteria: Participants are excluded from the study if any of the following criteria apply:

* Participant with severe Hoffa-synovitis or large effusion-synovitis at screening.
* Participant with past joint replacement surgery of the index knee or participant is expected to have knee replacement within the upcoming 6 months after enrollment.
* Participant with anterior cruciate ligament tears in the index knee.
* Participant with destabilizing meniscal tears (ie, root tears) or meniscus extrusion of \>5 mm in the index knee.
* Participant with a history or presence of (as identified by MRI at screening), osteonecrosis, subchondral insufficiency fracture, atrophic osteoarthritis, large subchondral cysts, osteoporosis, osteomalacia of the appendicular bones, rapidly progressing osteoarthritis (RPOA) Type I or Type II or accelerated knee OA (AKOA), pathologic fracture, bone bruise, primary or metastatic tumor, malignant bone marrow infiltration, joint infection, in the index knee.
* Participant with concurrent medical or arthritic conditions that could interfere with evaluation of the index knee joint including, autoimmune diseases, metabolic diseases, gout/pseudogout, hemochromatosis, acromegaly, fibromyalgia, rheumatoid arthritis, Paget's disease, Ehlers-Danlos Syndrome, Gaucher's disease, Stickler's syndrome, joint infection, haemophilia, haemochromatosis, neuropathic arthropathy or other inflammatory arthropathies in any joint.
* Participant with documented significant malalignment of the anatomical axis (medial angle formed by the femur and tibia) of the target knee as assessed by visual inspection of the lower limb by an orthopedist.
* Presence of surgical hardware or other foreign bodies in the index knee.
* Participant had IA injections to any knee within 3 months prior to inclusion or planned within the study period, including but not limited to glucocorticoids, hyaluronic acid, blood-derived cell concentrates, gene therapies, or human serum albumin.
* Participant with a history of significant trauma or surgery (eg., open or arthroscopic) within 12 months prior to screening.
* Participant with clinical hip osteoarthritis or hip prosthesis recently implanted (within 1 year prior to screening) on the side of the index knee or hip replacement on either side planned within the study period.
* Coronary stent within past 6 months, unstable ischemic heart disease, including acute myocardial infarction within past 1 year prior to screening or unstable angina in the 6 months prior to screening or during the screening period.
* Cardiomyopathy, as defined by Stage III-IV (New York Heart Association) cardiac failure, or other relevant cardiovascular disorder that in the investigator's judgement may put participant at risk.
* Abnormal laboratory test(s) at Screening
* Participant is bound to use a wheelchair or walking frame, or participant is bed bound.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Where this trial is running

Berlin

• Investigational Site Number : 2760001 — Berlin, Germany (Recruiting)

Study contacts

• Study coordinator: Trial Transparency email recommended (Toll free for US & Canada)

Conditions Osteoarthritis