Intraperitoneal bupivacaine versus saline to reduce pain after open appendectomy
Official title: Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy
Run by Services Institute of Medical Sciences, Pakistan · NCT07429448 · Data updated 2026-11-12
This will test whether placing bupivacaine into the abdominal cavity during open appendectomy reduces postoperative pain more than saline for adults who come to the emergency department.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Services Institute of Medical Sciences, Pakistan Government |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | December 16, 2025 |
| Main results expected | June 16, 2026 |
| Study ends | June 16, 2026 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT07429448 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults presenting to the emergency department for open appendectomy who do not have perforation, uncontrolled medical illness, chronic pain or analgesic use, pregnancy, or allergy to bupivacaine are the intended participants.
✕Probably not a fit
Patients with perforated appendicitis, uncontrolled medical conditions, chronic pain or chronic analgesic use, pregnant women, children, and those allergic to bupivacaine are excluded and therefore unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this Phase 1 interventional study, adults undergoing emergency open appendectomy receive intraperitoneal instillation of either bupivacaine or normal saline as preemptive analgesia. Clinical outcomes related to postoperative pain and immediate recovery are compared between the two groups. Key exclusions include perforated appendix, uncontrolled medical disease, chronic pain or analgesic use, pregnancy, and allergy to bupivacaine. The trial is conducted at Services Hospital Lahore under the lead sponsor Sardar Umer Rehman.
Why it matters
Potential benefit: If successful, patients could have less postoperative pain and need fewer opioid pain medications after open appendectomy.
How similar studies have gone: Intraperitoneal local anesthetic instillation has been used in other abdominal surgeries with mixed but often positive effects on postoperative pain, while its specific application in open appendectomy is less extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting to the emergency department undergoing open appendectomy. Exclusion Criteria: * Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air). * Uncontrolled medical disease (DM: BSL \>200mg/dl, HTN: BP \>140/90) * History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records) * Alcoholics * History of chronic pain or patients on analgesic medications * Pregnant females * History of allergy to bupivacaine/ ketorolac as determined on history * Children, Adolescents and patients with mental illness.
Where it's running
-
Services Institute of Medical Sciences/ Services Hospital Lahore
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Dr Sardar Umar Rehman, MBBS
- Email: umersardar578@gmail.com
- Phone: +923319326657
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.