Intra-Prostatic Epinephrine Injection During TURP for Large Prostates
Official title: Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate: Exploring Its Role in Optimizing Surgical Outcomes
Run by Benha University · NCT07733167 · Data updated 2026-11-12
This study tests whether injecting epinephrine into the prostate during TURP for large prostates improves surgical outcomes in men who have not had success with medical therapy.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 40 Years and up |
| Sex | Men only |
| Enrollment | 80 (estimated) |
| Sponsor | Benha University Academic / other |
| Locations | 1 site (Banhā, Qalyubia Governorate) |
| Status | Recruiting |
| Started | March 20, 2025 |
| Main results expected | March 20, 2026 |
| Study ends | October 20, 2026 |
| Registry record updated | July 29, 2026 |
| Trial ID | NCT07733167 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men indicated for prostate surgery (TURP) with an 80–100 gram prostate who have not responded to medical therapy.
✕Probably not a fit
Patients with severe cardiovascular disease, coagulopathy, endocrine tumors, or recent relevant urological procedures may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 3 interventional trial examines the addition of intra-prostatic epinephrine injection to the standard bipolar TURP procedure for large prostates (80–100 g). Eligible participants are men undergoing TURP after failed medical therapy. The study compares outcomes with the epinephrine-enhanced approach to typical surgical care, focusing on safety and effectiveness in optimizing perioperative results. Key exclusion criteria include uncontrolled cardiovascular conditions, significant coagulopathy, certain endocrine disorders, recent urological surgeries, and recent 5-alpha reductase inhibitor use. The trial is led by Benha University with site locations in Banha, Egypt.
Why it matters
Potential benefit: If successful, the approach could reduce bleeding and improve recovery during TURP for large prostates.
How similar studies have gone: Prior studies in similar surgical contexts have explored vasoconstrictive agents to optimize outcomes, but this specific epinephrine-in-prostate approach during TURP is being evaluated for its safety and effectiveness.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Indication for Prostate Surgery or Procedure - Patients undergoing transurethral resection of the prostate (TURP) * Prostate from 80 to 100 gm * Failed medical therapy Exclusion Criteria: * Uncontrolled Hypertension - Patients with significantly high blood pressure despite medication therapy. * Unstable angina, recent myocardial infarction, arrhythmias, or severe heart failure. * Significant Coagulopathy - Patients with bleeding disorders or on anticoagulants where excessive vasoconstriction may lead to tissue necrosis or inadequate perfusion * Hyperthyroidism, Pheochromocytoma or Endocrine Disorders - Patients with catecholamine-secreting tumors or other conditions that can lead to excessive sympathetic stimulation. * Treatment in the last 3 months with 5-alpha reductase inhibitors. * Genitourinary cancer, urinary tract lithiasis, and urological surgery within the last 3 months
Where it's running
-
Ahmed Abdelraouf Saad
Banhā, Qalyubia Governorate, Egypt Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.