Intra-arterial neuroprotection for ischemic stroke patients who missed reperfusion therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center interventional study delivers neuroprotective agents directly into the cerebral artery of adults with acute ischemic stroke who did not receive intravenous thrombolysis or endovascular thrombectomy, or whose deficits worsened within 48 hours. Eligible patients are adults with moderate-to-severe deficits (NIHSS 6–20) and good premorbid function (mRS 0–1). The primary focus is on safety and feasibility of the intra-arterial approach, with monitoring for hemorrhage, organ toxicity, and neurological outcomes. Treatment is performed at the Department of Neurology, General Hospital of Northern Theater Command in Shenyang without a randomized control arm.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years;
2. Major neurologic deficits: 6≤NIHSS≤20;
3. Missing recanalization therapy (IVT or EVT) or progressive stroke, which was defined as symptoms worsen in 48 hours (an increase in NIHSS more than 4);
4. Premorbid mRS 0 or 1;
5. Signed informed consent.

Exclusion Criteria:

1. Modified Rankin Score \>2 caused by a history of prior stroke;
2. Patients who underwent intravenous thrombolysis or Endovascular treatment;
3. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<80000/mm3;
4. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
5. Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
6. Unsuitable for this clinical studies assessed by researcher.

Where it's running

• Department of Neurology, General Hospital of Northern Theater Command
  Shenyang, China Recruiting

Study contacts

• Study coordinator: Hui-Sheng T Chen, Ph.D.
• Email: chszh@aliyun.com
• Phone: +8613352452086

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.