Internet therapy for prolonged grief disorder
Official title: Efficacy and Mechanisms of Change of Online Cognitive Behavioural Therapy for Prolonged Grief Disorder After Loss: a Three-armed Randomised Control Trial
Run by Uppsala University · NCT06667674 · Data updated 2026-11-12
This study is testing if online therapy can help adults with prolonged grief feel better after losing a loved one.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 270 (estimated) |
| Sponsor | Uppsala University Academic / other |
| Locations | 2 sites (Uppsala and 1 other locations) |
| Status | Recruiting |
| Started | April 23, 2025 |
| Main results expected | July 2027 |
| Study ends | July 2028 |
| Registry record updated | April 29, 2025 |
| Trial ID | NCT06667674 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults residing in Sweden who have experienced the death of a loved one at least six months prior and are suffering from prolonged grief disorder.
✕Probably not a fit
Patients with ongoing severe psychiatric issues or those requiring more urgent care may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of internet-delivered Cognitive Behavioral Therapy (iCBT) in reducing symptoms of prolonged grief disorder in adults who have lost a loved one. Participants will be randomly assigned to either the iCBT group, an active control group, or a waitlist control group. The study aims to assess the short and long-term effects of iCBT on symptoms of prolonged grief, posttraumatic stress, and depression, while also exploring the mechanisms that contribute to its effectiveness. Follow-up assessments will be conducted at 6 and 12 months post-treatment to gauge the lasting impact of the intervention.
Why it matters
Potential benefit: If successful, this treatment could significantly alleviate prolonged grief symptoms and improve mental health outcomes for affected individuals.
How similar studies have gone: Previous studies have indicated that Cognitive Behavioral Therapy can be effective for prolonged grief, but this trial aims to expand on that with a larger sample size and comprehensive follow-up assessments.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Currently residing in Sweden * Lost a relative or close friend to any cause of death at least six months ago * Suffers from prolonged grief disorder Exclusion Criteria: * Ongoing severe psychiatric problems that may prevent treatment implementation or require more urgent care (e.g., participants with untreated psychotic disorder, untreated bipolar disorder, ongoing substance abuse, elevated suicide risk) * Change in dosage of any medication for mental health issues (e.g., antidepressant medication) in the past four weeks or in the next two months
Where it's running
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Region Uppsala, KBT via nätet, Nära vård digitalt
Uppsala, Sweden Recruiting -
Uppsala university, Dep of Womens and Childrens Health
Uppsala, Sweden Recruiting
Study contacts
- Study coordinator: Josefin Sveen, Professor
- Email: josefin.sveen@uu.se
- Phone: +46 738 66 70 87
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Noninvasive brain stimulation to help prolonged grief
This study tests whether repetitive transcranial magnetic stimulation (rTMS) can help adults with prolonged grief disorder who are coping poorly.
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Psilocybin to help people with prolonged grief disorder
This study will test whether a single 25 mg dose of psilocybin can reduce grief and trauma symptoms in adults with prolonged grief disorder.
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8-week mindfulness program for adults with prolonged grief disorder
This pilot tries an 8-week mindfulness training to see if it reduces grief symptoms and lowers stress-related brain and body responses in adults aged 18–60 with prolonged grief disorder.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.