Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Internet therapy for prolonged grief disorder

Official title: Efficacy and Mechanisms of Change of Online Cognitive Behavioural Therapy for Prolonged Grief Disorder After Loss: a Three-armed Randomised Control Trial

Run by Uppsala University · NCT06667674 · Data updated 2026-11-12

This study is testing if online therapy can help adults with prolonged grief feel better after losing a loved one.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment270 (estimated)
SponsorUppsala University
Academic / other
Locations2 sites (Uppsala and 1 other locations)
StatusRecruiting
StartedApril 23, 2025
Main results expectedJuly 2027
Study endsJuly 2028
Registry record updatedApril 29, 2025
Trial IDNCT06667674 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults residing in Sweden who have experienced the death of a loved one at least six months prior and are suffering from prolonged grief disorder.

Probably not a fit

Patients with ongoing severe psychiatric issues or those requiring more urgent care may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of internet-delivered Cognitive Behavioral Therapy (iCBT) in reducing symptoms of prolonged grief disorder in adults who have lost a loved one. Participants will be randomly assigned to either the iCBT group, an active control group, or a waitlist control group. The study aims to assess the short and long-term effects of iCBT on symptoms of prolonged grief, posttraumatic stress, and depression, while also exploring the mechanisms that contribute to its effectiveness. Follow-up assessments will be conducted at 6 and 12 months post-treatment to gauge the lasting impact of the intervention.

Why it matters

Potential benefit: If successful, this treatment could significantly alleviate prolonged grief symptoms and improve mental health outcomes for affected individuals.

How similar studies have gone: Previous studies have indicated that Cognitive Behavioral Therapy can be effective for prolonged grief, but this trial aims to expand on that with a larger sample size and comprehensive follow-up assessments.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Currently residing in Sweden
* Lost a relative or close friend to any cause of death at least six months ago
* Suffers from prolonged grief disorder

Exclusion Criteria:

* Ongoing severe psychiatric problems that may prevent treatment implementation or require more urgent care (e.g., participants with untreated psychotic disorder, untreated bipolar disorder, ongoing substance abuse, elevated suicide risk)
* Change in dosage of any medication for mental health issues (e.g., antidepressant medication) in the past four weeks or in the next two months

Where it's running

  • Region Uppsala, KBT via nätet, Nära vård digitalt
    Uppsala, Sweden
    Recruiting
  • Uppsala university, Dep of Womens and Childrens Health
    Uppsala, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Noninvasive brain stimulation to help prolonged grief

    This study tests whether repetitive transcranial magnetic stimulation (rTMS) can help adults with prolonged grief disorder who are coping poorly.

    Recruiting Bruyère Health Research Institute. · Ottawa, Ontario · NCT06953596

  • Psilocybin to help people with prolonged grief disorder

    This study will test whether a single 25 mg dose of psilocybin can reduce grief and trauma symptoms in adults with prolonged grief disorder.

    Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06724289

  • 8-week mindfulness program for adults with prolonged grief disorder

    This pilot tries an 8-week mindfulness training to see if it reduces grief symptoms and lowers stress-related brain and body responses in adults aged 18–60 with prolonged grief disorder.

    Recruiting University Hospital, Caen · Caen, Calvados · NCT06017765

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.