International registry for spontaneous coronary artery dissection
The International Spontaneous Coronary Artery Dissection "iSCAD" Registry (SCAD)
This study is creating a global database to learn more about spontaneous coronary artery dissection (SCAD) and help improve care for people who have it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | SCAD Alliance Academic / other |
| Locations | 31 sites (Los Angeles, California and 30 other locations) |
| Trial ID | NCT04496687 on ClinicalTrials.gov |
What this trial studies
The iSCAD Registry aims to create an international, multicenter database to enhance understanding of spontaneous coronary artery dissection (SCAD), a condition that can lead to serious cardiac events. This observational study will collect both prospective and retrospective clinical data from participants diagnosed with SCAD to analyze its natural history and prognosis. By increasing participant recruitment and statistical power, the registry seeks to develop best practices and clinical guidelines for preventing SCAD and its recurrence.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older with a new diagnosis or history of spontaneous coronary artery dissection confirmed by coronary angiography.
Not a fit: Patients with coronary dissection due to atherosclerosis or iatrogenic injury will not benefit from this study.
Why it matters
Potential benefit: If successful, this registry could lead to improved prevention strategies and treatment guidelines for patients suffering from SCAD.
How similar studies have performed: While SCAD is an under-researched area, the collaborative approach of this registry may build on previous observational studies, though it is largely novel in its comprehensive international scope.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either: 1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or 2. Outpatient cardiovascular clinics of enrolling medical centers. Participants must be: * 18 years of age or older * Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA * Suspected SCAD by coronary angiography Exclusion Criteria: 1. Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury 2. Inability to provide informed consent 3. Inability to complete study-related patient questionnaires 4. Inability to understand and complete patient questionnaires independently
Where this trial is running
Los Angeles, California and 30 other locations
- Cedars Sinai — Los Angeles, California, United States (Recruiting)
- UCLA (University of California, Los Angeles) — Los Angeles, California, United States (Recruiting)
- Kaiser Permanente Northern California — San Francisco, California, United States (Recruiting)
- University of Colorado — Aurora, Colorado, United States (Recruiting)
- Hartford Hospital — Hartford, Connecticut, United States (Recruiting)
- University of South Florida — Tampa, Florida, United States (Recruiting)
- Emory Healthcare System — Atlanta, Georgia, United States (Recruiting)
- Northwestern Medicine — Chicago, Illinois, United States (Recruiting)
- University of Kentucky — Lexington, Kentucky, United States (Terminated)
- Johns Hopkins — Baltimore, Maryland, United States (Recruiting)
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
- St. Luke's Mid America — Kansas City, Missouri, United States (Recruiting)
- Washington University — Saint Louis, Missouri, United States (Terminated)
- Dartmouth-Hitchcock — Lebanon, New Hampshire, United States (Recruiting)
- Catholic Medical Center — Manchester, New Hampshire, United States (Recruiting)
- Mount Sinai — New York, New York, United States (Recruiting)
- Columbia University Medical Center — New York, New York, United States (Recruiting)
- Atrium Health Sanger Heart and Vascular Institute — Charlotte, North Carolina, United States (Recruiting)
- University Hospitals--Case Western — Cleveland, Ohio, United States (Recruiting)
- Oklahoma Heart — Oklahoma City, Oklahoma, United States (Terminated)
- Providence — Portland, Oregon, United States (Recruiting)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (Recruiting)
- Allegheny General Hospital, Allegheny Health Network — Pittsburgh, Pennsylvania, United States (Recruiting)
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (Recruiting)
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (Recruiting)
- UT Southwestern — Dallas, Texas, United States (Recruiting)
- Intermountain — Murray, Utah, United States (Recruiting)
- University of Virginia — Charlottesville, Virginia, United States (Recruiting)
- Inova Heart & Vascular Institute — Fairfax, Virginia, United States (Recruiting)
- University of Washington Medicine — Seattle, Washington, United States (Recruiting)
- Victor Chang Cardiac Research Institute — Darlinghurst, New South Wales, Australia (Recruiting)
Study contacts
- Principal investigator: Malissa Wood, MD — Member, Steering Committee
- Study coordinator: Esther Kim, MD, MPH
- Email: Soo.Kim@atriumhealth.org
- Phone: 704-373-0212
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.