Intensive training program for patients with hereditary spastic paraparesis
Official title: Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast
Run by Assistance Publique - Hôpitaux de Paris · NCT06229626 · Data updated 2026-11-12
This study tests if a 6-week intensive physical rehab program can help people with hereditary spastic paraparesis walk faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 4, 2024 |
| Main results expected | October 2026 |
| Study ends | October 2026 |
| Registry record updated | November 25, 2024 |
| Trial ID | NCT06229626 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with a confirmed molecular diagnosis of hereditary spastic paraparesis who can walk for 6 minutes with or without assistance.
✕Probably not a fit
Patients who have recently received botulinum toxin injections or those who are not currently engaged in physiotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of a 6-week intensive physical rehabilitation program aimed at improving walking speed in patients diagnosed with hereditary spastic paraparesis, specifically the SPG4 genotype. Participants will engage in additional physiotherapy sessions, totaling at least four sessions per week. The study is designed as a prospective, open, randomized trial with a control group to compare outcomes. The goal is to provide objective evidence of the benefits of increased physiotherapy frequency on gait disorders.
Why it matters
Potential benefit: If successful, this program could significantly enhance the walking ability and quality of life for patients with hereditary spastic paraparesis.
How similar studies have gone: Previous studies have indicated positive outcomes from physiotherapy in managing spasticity, suggesting that this approach may yield beneficial results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with molecular diagnosis of hereditary spastic paraparesis based on pathogenic variant of SPAST gene, * Walking possible for 6 minutes without human assistance (one or more technical aids are authorized: e.g. cane, walker, orthoses), * At least 1 physiotherapy session per week already in place. * Understanding of the protocol * Possibility of connecting to the Internet from home to access video material provided as part of the protocol. Exclusion Criteria: * Botulinum toxin injection within 2 months of protocol inclusion * Discontinuation of private physiotherapy, * Refusal to participate in the protocol, * Participation in another interventional clinical trial evaluating a health product or in a randomized clinical trial * Pregnant women * Not affiliated to a social security scheme or beneficiary of such a scheme * Patient under guardianship or trusteeship
Where it's running
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ICM, Hôpital Pitié-Salpêtrière
Paris, France Recruiting
Study contacts
- Study coordinator: Pauline Lallemant, MD
- Email: pauline.lallemant@icm-institute.org
- Phone: 1. 57.27.46.69
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.