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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Integrated recovery program for ICU survivors

Official title: Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) Program

Run by National Taiwan University Hospital · NCT06997822 · Data updated 2026-11-12

This trial will test whether combining a LINE Bot remote support system with in-person post-ICU clinic visits can reduce unplanned readmissions and improve physical and cognitive recovery for people who were intubated in the ICU.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment240 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Locations1 site (Taipei)
StatusRecruiting
StartedNovember 3, 2025
Main results expectedJuly 31, 2028
Study endsDecember 31, 2028
Registry record updatedDecember 3, 2025
Trial IDNCT06997822 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are ICU survivors who were intubated and mechanically ventilated, can walk independently prior to admission, can use a smartphone (LINE), and are being discharged home rather than to an institutional facility.

Probably not a fit

Patients discharged to institutional care, those with significant preexisting dementia or inability to participate in assessments, or those without a smartphone are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares an integrated aftercare program (LINE Bot remote monitoring plus scheduled in-person post-ICU recovery clinic visits) to usual follow-up for ICU survivors who received mechanical ventilation. The primary outcome is the rate of unplanned hospital readmissions and emergency department visits within six months after discharge. Secondary outcomes include physical mobility measures, inspiratory muscle strength, weight change, dysphagia, and cognitive function assessed at 3 and 6 months. The LINE Bot also includes a 'Thanks to Nurses' feature, and the study will measure ICU nurses' burnout and intention to leave at 6, 12, 18, and 24 months.

Why it matters

Potential benefit: If successful, the program could lower emergency visits and readmissions while improving mobility, breathing strength, weight recovery, and thinking skills after ICU stay.

How similar studies have gone: Previous work on post-ICU clinics and remote follow-up has shown mixed but promising results for reducing readmissions and improving function, and this study builds on that evidence while adding a novel nurse–patient communication feature.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* ICU survivors who had experienced endotracheal intubation and mechanical ventilation treatment.

Exclusion Criteria:

* ICU survivors who are unable to walk independently before admission
* ICU survivors who are unable to receive assessment (e.g., dementia or mental retardation)
* ICU survivors who don't have a smartphone.
* ICU survivors were discharged to institutional care facilities

Where it's running

  • National Taiwan University Hospital
    Taipei, Taiwan     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.