Integrated Biomedical Informatics for Managing Cerebral Aneurysms
@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux
University Hospital, Geneva · NCT05526352
This study is trying to build a detailed database about brain aneurysms to see what factors might increase the risk of them forming or bursting, and it's for patients with aneurysms, healthy volunteers, and their family members.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Geneva (other) |
| Locations | 22 sites (San Francisco, California and 21 other locations) |
| Trial ID | NCT05526352 on ClinicalTrials.gov |
What this trial studies
This project aims to create a comprehensive database specifically for intracranial aneurysms by collecting clinical histories, imaging data, and biological samples. It will evaluate risk markers for aneurysm formation and rupture, as well as prognostic factors for various management strategies. Participants include patients with diagnosed aneurysms, healthy volunteers, and family members of affected individuals. The data collected will help inform patient-specific management protocols and improve understanding of the condition.
Who should consider this trial
Good fit: Ideal candidates include individuals with angiographically proven intracranial aneurysms and their family members, as well as healthy volunteers.
Not a fit: Patients who are unable to provide informed consent or those who do not have an intracranial aneurysm will not benefit from this study.
Why it matters
Potential benefit: If successful, this project could lead to improved risk assessment and personalized treatment strategies for patients with intracranial aneurysms.
How similar studies have performed: While similar approaches have been explored, this specific integration of data for intracranial aneurysms is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * able to provide consent or, in the event that a patient is incapable of providing consent, that a person is legally authorized to do so on behalf of the patient according to legal and ethical requirements of the country where the clinical centre is located. Patients: * must have an angiographically proven intracranial aneurysm (MRA\< CTA\< DSA accepted).The determination of SAH requires the presence of a subarachnoid haemorrhage be verified on CT or by lumbar puncture. MRA: Magnetic Resonance Angiography CTA: Computed Tomography Angiography DSA: Digital Subtracted Angiography Exclusion Criteria: * failure of a candidate to contribute clinical data, * refusal to provide informed consent.
Where this trial is running
San Francisco, California and 21 other locations
- University of California — San Francisco, California, United States (RECRUITING)
- University of Cincinnati College of Medicine — Cincinnati, Ohio, United States (RECRUITING)
- University of Virginia — Virginia Beach, Virginia, United States (RECRUITING)
- Montreal Neurological Institute and Hospital, McGill University — Montreal, Canada (RECRUITING)
- Helsinki University Central Hospital — Helsinki, Finland (RECRUITING)
- Kuopio University Hospital — Kuopio, Finland (RECRUITING)
- ICAN — Nantes, France (RECRUITING)
- Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich — Munich, Germany (RECRUITING)
- University of Pecs — Pécs, Hungary (COMPLETED)
- Erasmus Medical Center — Rotterdam, Netherlands (COMPLETED)
- University Medical Center Utrecht — Utrecht, Netherlands (RECRUITING)
- Jagiellonian University Medical College — Krakow, Poland (RECRUITING)
- Barcelona Hospital General de Cataluna — Barcelona, Spain (COMPLETED)
- Hospital Clinic Barcelona — Barcelona, Spain (COMPLETED)
- IMIM - Hospital del Mar — Barcelona, Spain (RECRUITING)
- Neurochirurgie / Hôpitaux Universitaire de Genève — Geneva, Switzerland (RECRUITING)
- University Hospital of Lausanne (CHUV), CoLaus Datacenter — Lausanne, Switzerland (RECRUITING)
- Department of Neurosurgery, Cantonal Hospital St. Gallen — Sankt Gallen, Switzerland (RECRUITING)
- Klinik Hirslanded — Zurich, Switzerland (NOT_YET_RECRUITING)
- University College London — London, United Kingdom (RECRUITING)
- Radcliffe Infirmary — Oxford, United Kingdom (COMPLETED)
- Royal Hallamshire Hospital — Sheffield, United Kingdom (COMPLETED)
Study contacts
- Principal investigator: Philippe Bijlenga, PD MD PhD — Geneva University
- Study coordinator: Sven Hirsch, Dr
- Email: hirc@zhaw.ch
- Phone: +41 58 934 54 44
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Intracranial Aneurysm