Insights from the FAST-TRACK CABG Experience in Complex Multivessel Disease
Official title: FAST-CABG: Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, (CCTA) and Fractional Flow Reserve Derived by Computed Tomography (FFRCT)
Run by Centro Cardiologico Monzino · NCT07628270 · Data updated 2026-11-12
This study tests whether imaging-derived markers from CCTA and FFRCT can predict symptom relief and major cardiovascular outcomes after CCTA-guided CABG in people with complex multivessel disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Centro Cardiologico Monzino Academic / other |
| Locations | 1 site (Milan, MI) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | October 31, 2026 |
| Study ends | October 31, 2026 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT07628270 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with complex three-vessel or left main CAD who had a CCTA with FFRCT-guided CABG and available pre-CABG imaging, able to consent and comply with follow-up.
✕Probably not a fit
Patients without pre-CABG imaging, who did not receive surgical revascularization, or who refuse follow-up may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, prospective, multicenter European study analyzing patients from the FAST-TRACK CABG trial. It uses patient-reported outcome measures (Seattle Angina Questionnaire) and clinical outcomes (MACCE, NYHA class, cardiovascular hospitalization, and death) to explore prognostic value of imaging markers. Data include Lipoprotein(a) levels and pre-CABG CCTA imaging with FFRCT-guided revascularization. The aim is to determine if preoperative imaging biomarkers correlate with post-CABG symptom improvement and major adverse events. Enrollment requires informed consent and analyzable pre-CABG imaging.
Why it matters
Potential benefit: If successful, imaging markers could help predict which patients are likely to experience better symptom relief and fewer adverse events after CABG.
How similar studies have gone: Previous FAST-TRACK CABG work supports the value of CCTA-FFRCT in planning revascularization; this sub-analysis aims to extend those findings to patient-reported outcomes and events.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have analyzable pre-CABG CCTA imaging and received a successful CCTA-guided plus FFRCT CABG procedure. * Patient with known level of Lp(a) or with possibility to perform the test * Patent able to provide written informed consent as approved by the Ethical Committee Exclusion Criteria: * Patients without pre-CABG CCTA imaging or those with who did not receive surgical revascularization. * Current treatment with lipoprotein apheresis * Patients who refuse to receive clinical follow-up * Unable to give Informed Consent
Where it's running
-
Centro Cardiologico Monzino; IRCCS
Milan, Mi, Italy Recruiting
Study contacts
- Study coordinator: Gianluca Pontone, MD
- Email: gianluca.pontone@cardiologicomonzino.it
- Phone: 0258002574
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.