Comparing complete revascularization to culprit lesion only PCI in NSTEMI patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates whether performing multivessel percutaneous coronary intervention (PCI) is more effective than treating only the identified culprit lesion in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease. It is a prospective, randomized, controlled, multicenter, open-label trial that aims to provide insights into the benefits of complete revascularization. Participants will be randomly assigned to receive either complete revascularization or culprit-lesion only PCI. The study will assess outcomes related to heart health and recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* NSTEMI as suggested by high-sensitivity troponin algorithms
* Multivessel coronary artery disease
* Identifiable culprit lesion
* Informed consent

Exclusion Criteria:

* Age \<18 years
* Cardiogenic shock
* Sustained ventricular tachycardia (VT) or ventricular fibrillation (VF)
* Contraindication for coronary revascularization
* Prior coronary artery bypass graft
* Indication for coronary artery bypass graft surgery
* Non-culprit lesion located in the left main coronary artery
* Co-morbidity with life expectancy less than 6 months
* Type 2 myocardial infarction
* Pregnancy and breast feeding period

Where it's running

• Zentralklinik Bad Berka, Klinik für Kardiologie
  Bad Berka, Germany Recruiting
• Kerckhoff Klinik
  Bad Nauheim, Germany Recruiting
• Herz- und Diabeteszentrum NRW, Universitätsklinikum der Ruhr-Universität Bochum, Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie
  Bad Oeynhausen, Germany Recruiting
• BG Klinikum Unfallkrankenhaus Berlin gGmbH, Klinik für Innere Medizin/Kardiologie
  Berlin, Germany Recruiting
• Klinikum Bielefeld gem. GmbH, Klinik für Kardiologie und Internistische Intensivmedizin
  Bielefeld, Germany Recruiting
• Klinikum Links der Weser, Innere Medizin II
  Bremen, Germany Recruiting

+8 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Holger Thiele, MD, Prof. Dr.
• Email: holger.thiele@medizin.uni-leipzig.de
• Phone: +49 341 865-252025

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.