Infusing healthy mitochondria to treat cerebral ischemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to infuse healthy autologous mitochondria into the cerebral vessels of patients experiencing ischemia during standard endovascular reperfusion therapy. The approach is based on preclinical evidence suggesting that mitochondrial damage caused by ischemia can be reversed with such infusions. The trial will assess the safety and feasibility of this novel intervention in human subjects, specifically targeting those eligible for endovascular thrombectomy. The procedure will be conducted concurrently with clinically indicated treatments for acute large vessel occlusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible for endovascular thrombectomy to treat acute large vessel occlusion
* Eligible for angioplasty (microcatheter-based balloon/mechanical and chemical angioplasty) to treat acute cerebral vasospasm after aneurysmal subarachnoid hemorrhage
* Subjects for whom there is likely to be enough time to obtain meaningful consent from patient or legally-authorized representative

Exclusion Criteria:

* Unable to receive a brain MRI scan
* Known mitochondrial disease
* Hemodynamically unstable patients in whom standard of care endovascular reperfusion treatment cannot safely be performed or completed

Where it's running

• Harborview Medical Center
  Seattle, Washington, United States Recruiting

Study contacts

• Principal investigator: Melanie S Walker, MD — University of Washington
• Study coordinator: Study Coordinator
• Email: sanslab@uw.edu
• Phone: 206-897-5802

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.