Influenza vaccination for adults over 75 years old
Influenza Immunization in Adults Over Age 75
This study tests how well the flu vaccine works for adults over 75, especially looking at how a common virus might affect their immune response.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1025 (estimated) |
| Ages | 75 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Drugs / interventions | chemotherapy, radiation, methotrexate, prednisone |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT02200276 on ClinicalTrials.gov |
What this trial studies
This research investigates how the immune systems of older adults, specifically those over 75, respond to the influenza vaccine. It aims to understand the impact of chronic cytomegalovirus (CMV) infection on the immune response to the flu shot in this age group. The study will enroll 1,025 participants and assess both antibody responses and clinical protection from influenza. The findings could provide insights into improving vaccination strategies for the frail elderly population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 75 and older, regardless of their health status.
Not a fit: Patients with active malignancies, severe systemic inflammatory diseases, or those on immunosuppressive therapies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of influenza vaccinations in older adults, potentially reducing morbidity and mortality associated with influenza.
How similar studies have performed: Previous studies have indicated challenges in vaccine efficacy among older adults, particularly the frail elderly, suggesting that this research addresses a critical gap in understanding immune responses in this population.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults over age 75 years Exclusion Criteria: * Allergies to egg or vaccine * Active malignancies * On radiation or chemotherapy * Active systemic inflammatory diseases including rheumatoid arthritis, Crohn's disease, and ulcerative colitis * Acute exacerbation of chronic cardiopulmonary conditions including decompensated CHF or COPD * Taking oral steroids (such as prednisone) or immune modulating drugs (such as methotrexate). * Lacking the capacity to consent (individuals who do not understand what Flu shot is or need someone else to decide if s/he should get the Flu shot)
Where this trial is running
Baltimore, Maryland
- Johns Hopkins University; JHAAC 5501 Hopkins Bayview Circle, 1B84 — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Sean Leng — Johns Hopkins University
- Study coordinator: Trudymae Agboka, M.S. Biology
- Email: tagboka1@jhmi.edu
- Phone: 410-550-5744
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.