Influenza vaccination for adults over 75 years old

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates how the immune systems of older adults, specifically those over 75, respond to the influenza vaccine. It aims to understand the impact of chronic cytomegalovirus (CMV) infection on the immune response to the flu shot in this age group. The study will enroll 1,025 participants and assess both antibody responses and clinical protection from influenza. The findings could provide insights into improving vaccination strategies for the frail elderly population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults over age 75 years

Exclusion Criteria:

* Allergies to egg or vaccine
* Active malignancies
* On radiation or chemotherapy
* Active systemic inflammatory diseases including rheumatoid arthritis, Crohn's disease, and ulcerative colitis
* Acute exacerbation of chronic cardiopulmonary conditions including decompensated CHF or COPD
* Taking oral steroids (such as prednisone) or immune modulating drugs (such as methotrexate).
* Lacking the capacity to consent (individuals who do not understand what Flu shot is or need someone else to decide if s/he should get the Flu shot)

Where it's running

• Johns Hopkins University; JHAAC 5501 Hopkins Bayview Circle, 1B84
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Sean Leng — Johns Hopkins University
• Study coordinator: Trudymae Agboka, M.S. Biology
• Email: tagboka1@jhmi.edu
• Phone: 410-550-5744

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.