Infant RSV Immunity: How early vs late first exposure may shape immune response and later asthma risk
Official title: Understanding the Impact of Early-life RSV Infections on Infant Immunity and Long-term Health
Run by University of British Columbia · NCT07653347 · Data updated 2026-11-12
This study follows 300 infants born in spring or fall to see how the timing of first RSV exposure affects their immune response and breathing health by age 3.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 6 Months |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | June 1, 2027 |
| Study ends | December 1, 2029 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07653347 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Infants born in April–June or September–November in British Columbia, and their birthing parent, planning to deliver at BC Women’s Hospital or nearby facilities.
✕Probably not a fit
Infants whose RSV exposure timing does not show meaningful patterns in immune response or respiratory outcomes may not experience benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort study of 300 parent-infant pairs in British Columbia, comparing infants exposed to RSV early (born Sept–Nov) versus later (born Apr–Jun) in their first year. Researchers will track immune responses after RSV seasons and respiratory outcomes at age 3, while also exploring gut and upper airway microbiota changes and how these relate to RSV risk. The study will observe natural exposure without assigned interventions, and will collect data on immune maturation and infection dynamics. It aims to identify factors associated with stronger antibody responses and how seasonal timing influences long-term respiratory outcomes.
Why it matters
Potential benefit: If successful, findings could improve understanding of RSV timing on immune development and asthma risk, guiding future prevention strategies.
How similar studies have gone: Previous infant RSV studies have explored timing and immunity, but this study’s birth-season comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Birthing parent/child pairs with a delivery date in April, May or June or September, October or November who delivered or are planning to deliver at BC Women's Hospital + Health Centre or a nearby, local hospital. Exclusion Criteria: Severe pregnancy-related complications or chronic medical conditions in the children making them automatically eligible to receiving RSV immunoprophylaxis in British Columbia (e.g. infants born prematurely \< 35 weeks of gestation, or with chronic medical conditions).
Where it's running
-
BC Women's Hospital and Health Centre
Vancouver, British Columbia, Canada Recruiting
Study contacts
- Study coordinator: Pascal Lavoie, MDCM PhD FRCPC
- Email: plavoie@bcchr.ca
- Phone: 604-875-2135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.