Inducing tolerance to hypoxia and hypothermia in warfighters
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
This study is testing whether certain approved drugs can help military personnel perform better in extreme conditions by improving how their red blood cells deliver oxygen during low oxygen and cold temperatures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 88 Years |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT06129825 on ClinicalTrials.gov |
What this trial studies
This study focuses on optimizing the performance of military personnel in extreme environments by investigating the effects of approved drugs on red blood cell (RBC) performance during hypoxia and hypothermia. The approach involves repurposing these drugs to enhance oxygen delivery and physiological performance under stress. The study will evaluate RBC attributes through rigorous benchtop and in vivo models, assessing gender-specific effects and quantifying performance under controlled conditions. The goal is to identify effective pharmacologic interventions that can improve cognitive and exercise capacity in challenging operational settings.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 and older who weigh at least 110 pounds.
Not a fit: Patients with ongoing infections, pregnant individuals, non-English speakers, and those aged 89 and over may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could enhance the safety and performance of warfighters in extreme conditions, potentially reducing injury risk and improving mission outcomes.
How similar studies have performed: While the approach of repurposing drugs for RBC performance in extreme conditions is innovative, similar studies have shown promise in enhancing physiological responses in stressful environments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject is \>/= 18years of age. * Subject weighs a minimum of 110lbs * Subject must be generally healthy individual Exclusion Criteria: * Suspected or diagnosed with ongoing (chronic) or acute infection * Pregnant * Non-English speaking * Ages 89 and over
Where this trial is running
Baltimore, Maryland
- University of Maryland Baltimore — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Allan Doctor, PhD — University of Maryland, Baltimore
- Study coordinator: Allan Doctor, PhD
- Email: Adoctor@som.umaryland.edu
- Phone: 314-791-0297
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.