Indomethacin vs diclofenac to prevent pancreatitis after ERCP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–90 with a native papilla scheduled for ERCP are randomized to receive either 100 mg rectal indomethacin or 100 mg rectal diclofenac before the procedure. Key exclusions include recent NSAID use, planned pancreatic duct stenting, recent acute pancreatitis, significant bleeding risk or renal dysfunction, pregnancy, and inability to consent. The trial measures the incidence of post-ERCP pancreatitis and monitors NSAID-related adverse events. It is a multicenter head-to-head comparison conducted at tertiary hospitals in China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-90 years old patients with native papilla who planned to undergo ERCP

Exclusion Criteria:

* Previous biliary sphincterotomy and papillary large balloon dilation
* Planned for placements of pancreatic duct stents (eg. pancreatic duct strictures, planned ampullectomy)
* Allergy to NSAIDs
* The administration of NSAIDs within 7 days
* Not suitable for NSAIDs administration (gastrointestinal hemorrhage within 4 weeks, renal dysfunction \[Cr \>1.4mg/dl=120umol/l\]; presence of coagulopathy before the procedure)
* Acute pancreatitis within 7 days before ERCP or acute pancreatitis with obvious Pancreatic edema and peripancreatic fluid collections
* Hemodynamical instability
* Pregnancy or lactation
* Unable to give informed consent

Where it's running

• The first medical center, Chinese PLA General Hospital
  Beijing, Beijing Municipality, China Recruiting
• The Second Affiliated Hospital of Chongqing Medical University
  Chongqing, Chongqing Municipality, China Recruiting
• Department of Gastroenterology, Hongai Hospital
  Xiamen, Fujian, China Recruiting
• Harbin Medical University Affiliated Fourth Hospital
  Harbin, Heilongjiang, China Recruiting
• Zhaolei181220@163.Com
  Harbin, Heilongjiang, China Recruiting
• Huaihe Hospital of Henan University
  Kaifeng, Hennan, China Recruiting

Study contacts

• Study coordinator: Yanglin Pan, MD
• Email: yanglinpan@hotmail.com
• Phone: 86-84771536

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Short-stay aggressive hydration to prevent post-ERCP pancreatitis

  This trial tests whether a short, high-volume IV hydration with Lactated Ringer's plus a rectal indomethacin can prevent post-ERCP pancreatitis in adults undergoing ERCP.

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• Biomechanical Factors During ERCP for Digestive Specialists

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• Phosphate therapy for adults with acute pancreatitis

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  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT07681050

• Cold water rinse plus rectal indomethacin to prevent pancreatitis after ERCP

  This will test whether rinsing the papilla with cold water plus a rectal indomethacin dose lowers the chance of pancreatitis for adults undergoing ERCP.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07330284

• Preventing complications after high-risk Whipple (pancreatoduodenectomy) with hydrocortisone, octreotide, and a teres ligament patch

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  Recruiting Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07262957

• Scrambler therapy for chronic pancreatitis pain

  We will test whether Scrambler Therapy can reduce persistent abdominal pain in adults with chronic pancreatitis who haven't found relief from standard treatments.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07174609

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.