Individualized PEEP for preventing lung complications in obese patients after surgery
Effects of Individualized Positive End-expiratory Pressure Guided by Driving Pressure on Postoperative Atelectasis After Bariatric Surgery in Patients With Morbid Obesity: A Single-center, Prospective, Randomized Controlled Study
This study is testing if a personalized breathing support method can help prevent lung problems in very overweight patients after they have bariatric surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 52 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Qianfoshan Hospital Academic / other |
| Locations | 1 site (Jinan, Shandong) |
| Trial ID | NCT06181279 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of individualized positive end-expiratory pressure (PEEP) guided by driving pressure on postoperative atelectasis in morbidly obese patients undergoing bariatric surgery. The study aims to determine whether a tailored PEEP strategy can reduce the incidence of atelectasis compared to a fixed PEEP approach. By focusing on the unique respiratory mechanics of each patient, the trial seeks to enhance lung protection during and after surgery. It is a single-center, randomized controlled trial designed to provide insights into optimal ventilation strategies for this high-risk population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 60 with a body mass index of 40 kg/m2 or higher undergoing bariatric surgery.
Not a fit: Patients with severe respiratory diseases, recent respiratory infections, or contraindications to PEEP may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of postoperative lung complications in morbidly obese patients.
How similar studies have performed: Previous studies have shown that individualized PEEP strategies can improve oxygenation in both obese and non-obese patients, suggesting potential success for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 60 years old; * Body mass index (BMI) ≥ 40 kg/m2; * ASA classification I to III; * Signing the informed consent form for this clinical study; Exclusion Criteria: * Respiratory infection within 4 weeks; severe respiratory system diseases; history of pulmonary and/or thoracic surgery; neuromuscular dysfunction; * Serious cardiac, renal or haematopoietic diseases; * Contraindications to PEEP；
Where this trial is running
Jinan, Shandong
- Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University — Jinan, Shandong, China (Recruiting)
Study contacts
- Study coordinator: yong t Sun, Ph.D
- Email: sunyongtao1979@163.com
- Phone: 18660795201
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.