Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Indirect calorimetry-guided parenteral nutrition in adults with cancer

Official title: Comparing Measured Resting Energy Expenditure to Weight-Based Equations for Parenteral Nutrition Prescribing in Oncology Patients: A Randomized Trial

Run by Fox Chase Cancer Center · NCT07776704 · Data updated 2026-11-12

This study tests whether using indirect calorimetry to guide parenteral nutrition dosing is feasible and helps cancer patients who can’t meet nutrition needs by eating or tube feeding.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorFox Chase Cancer Center
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedAugust 21, 2025
Main results expectedJuly 2028
Study endsJanuary 2029
Registry record updatedAugust 20, 2026
Trial IDNCT07776704 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with cancer who require parenteral nutrition for at least one week and can communicate in English.

Probably not a fit

Patients not benefiting may include those with rapidly changing energy needs, organ failure, or conditions where calorimetry-guided dosing is not applicable.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, open-label pilot study enrolling 50 adults with cancer who require parenteral nutrition. Participants are assigned to either standard weight-based PN dosing or PN dosing guided by indirect calorimetry to measure energy needs. The study looks at feasibility, acceptability, changes in PN prescriptions, adverse events, quality of life, and survival to assess potential benefits and practical use in oncology care.

Why it matters

Potential benefit: If successful, patients may receive more accurate PN dosing leading to better nutrition and quality of life.

How similar studies have gone: Previous work in related areas suggests energy-based PN dosing can be feasible, but this approach in oncology PN is early-stage and pilot in nature.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged ≥18 years
* Diagnosis of cancer
* Requirement for PN ≥1 week
* Ability to provide informed consent
* English-speaking

Exclusion Criteria:

* Hospice enrollment
* Mechanical ventilation
* Chest tube or drain
* Continuous renal replacement therapy
* Supplemental oxygen

Where it's running

  • Fox Chase Cancer Center
    Philadelphia, Pennsylvania, United States
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.