Indapamide to reduce urinary calcium in post-surgical hypoparathyroidism
Official title: Treatment With Indapamide in Patients With Post-Surgical Hypoparathyroidism
Run by University of Aarhus · NCT07034677 · Data updated 2026-11-12
This trial will test whether taking indapamide once daily for 14 days lowers urinary calcium in adults with chronic post-surgical hypoparathyroidism.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus) |
| Status | Recruiting |
| Started | August 2025 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | August 11, 2025 |
| Trial ID | NCT07034677 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with chronic (over 1 year) post-surgical hypoparathyroidism who require ≥1 µg/day active vitamin D, have ionized calcium 1.15–1.25 mmol/L, adequate 25(OH)D and magnesium levels, and eGFR ≥30 ml/min/1.73 m2 are ideal candidates.
✕Probably not a fit
Patients with eGFR <30 ml/min/1.73 m2, low plasma potassium (<3.5 mmol/L), symptomatic hypotension or systolic BP <100 mmHg, recent or active non-thyroid cancer, pregnancy/planning/breastfeeding, or other disorders affecting calcium metabolism are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with chronic post-surgical hypoparathyroidism receive indapamide 1.5 mg sustained release or placebo for 14 days while clinicians monitor blood chemistry and urine output. Participants complete weekly blood tests and 24-hour urine collections every two weeks to track calcium and electrolyte changes. The main outcome is change in urinary calcium excretion after the treatment period. The protocol targets patients on stable active vitamin D therapy to see if indapamide can reduce hypercalciuria without causing significant electrolyte or blood pressure problems.
Why it matters
Potential benefit: If successful, indapamide could reduce urinary calcium loss and lower the risk of kidney stones or renal calcium-related complications in these patients.
How similar studies have gone: Thiazide and thiazide-like diuretics have a well-established effect of lowering urinary calcium in other conditions, but controlled data specifically testing indapamide in post-surgical hypoparathyroidism are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Chronic post surgical hypoparathyroidism diagnosed \> 1 year ago 2. Age ≥ 18 years 3. Require treatment with active vitamin D ≥ 1 µg/day 4. Ionized plasma calcium between 1.15-1.25 mmol/L 5. 25(OH)D vitamin ≥ 50 nmol/L 6. Plasma magnesium \> 0.65 mmol/L 7. Able to read and understand Danish 8. Willing and able to sign the informed consent form Exclusion Criteria: 1. Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m3 2. Active cancer or former (except thyroid and basal cell skin) cancer treatment \< 1 year ago 3. Pregnancy, pregnancy plans, or breastfeeding \< 1 year ago 4. Abnormal arterial pressure at time of screening defined as symptomatic hypotension or systolic blood pressure \< 100 mmHg 5. Plasma potassium \< 3.5 mmol/L 6. Any current disease that might affect the calcium metabolism such as but not limited to: 1. Recent prolonged immobility 2. Untreated diabetes (HbA1c \> 53 mmol/mol) 3. Severe liver disease or hepatic encephalopathy 4. Untreated thyroid disease 7. Current disease that might affect gastrointestinal absorption 8. Use of medications such as lithium or diuretics within 4 weeks prior to start of treatment 9. Known allergy or sensitivity to Indapamide, its excipients or sulfonamides 10. Known galactosemia, lactase deficiency, or glucose-galactose malabsorption
Where it's running
-
Department of Endocrinology and Internal Medicine
Aarhus, Denmark Recruiting
Study contacts
- Study coordinator: Sarah Thornhøj, MD
- Email: sarthorn@rm.dk
- Phone: +4540491821
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Early detection and prevention of symptomatic post-surgical hypoparathyroidism after thyroid surgery
This project tests whether measuring parathyroid hormone earlier after thyroid surgery and starting calcium plus active vitamin D when needed can reduce how many patients develop symptoms from low parathyroid function.
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This trial will test whether using the handheld PTeye device during total thyroidectomy in adults reduces the chance of low blood calcium after surgery.
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Parathyroid tissue transplant into the forearm for chronic hypoparathyroidism
This project will try transplanting donated parathyroid tissue into the forearm of adults with chronic hypoparathyroidism to raise PTH and help normalize their calcium and phosphorus levels.
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PTeye versus surgeon’s eye for finding and protecting parathyroid glands during total thyroid removal
This trial will test whether using the PTeye near-infrared probe during first-time total thyroidectomy in adults helps surgeons find and preserve parathyroid glands better than using the surgeon’s naked eye.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.