Increasing daily physical activity for teens with chronic kidney disease
Official title: Physical Activity in Adolescents With Chronic Kidney Disease
Run by Children's Hospital of Philadelphia · NCT06624358 · Data updated 2026-11-12
This 12-week program will test if an online physical-activity plan can add about 15 minutes of moderate-to-vigorous activity per day for adolescents (ages 13–18) with chronic kidney disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 13 Years to 18 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Children's Hospital of Philadelphia Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | September 30, 2025 |
| Main results expected | June 2028 |
| Study ends | December 2028 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT06624358 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adolescents aged 13–18 with CKD stage II–V who are not on dialysis or transplanted, speak English, have parental permission, and have baseline activity under 45 minutes/day are ideal candidates.
✕Probably not a fit
Those on dialysis, with a prior solid-organ transplant, who are non-ambulatory, pregnant or lactating, have very high baseline activity, limited English proficiency, or medical conditions that make activity unsafe are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Cardiovascular disease is a leading cause of illness and early death in youth with chronic kidney disease, and these adolescents are generally less active than their peers. Investigators will enroll 64 adolescents with CKD into a 12-week physical activity intervention and use the Multiphase Optimization Strategy (MOST) framework to optimize which components work best. The optimization trial aims to find intervention elements that increase average daily moderate-to-vigorous physical activity by 15 minutes, a clinically meaningful change. Intervention components grounded in behavior-change theory will be delivered via the Way to Health web platform to reduce clinic time and resource barriers.
Why it matters
Potential benefit: If successful, the program could increase daily activity, improve fitness and quality of life, and help lower future cardiovascular risk in adolescents with CKD.
How similar studies have gone: Physical-activity programs have improved activity in healthy youths, but optimized, web-delivered interventions specifically tested in adolescents with CKD are limited, so this approach is relatively novel in this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: For adolescent participants: 1. Males or females age 13 - 18 years 2. Diagnosis of CKD stage II - V not yet on dialysis or with a transplant 3. English proficiency 4. Parental/guardian permission (informed consent), and if applicable, child assent For caregiver participants: 1. Parent/legal guardian of an enrolled adolescent participant 2. English proficiency Exclusion Criteria: For adolescent participants: 1. Pregnant or lactating 2. Non-ambulatory 3. Have high physical activity at baseline (\>45 min/day of MVPA) 4. Provide \<2 days of physical activity data during the run-in period 5. Have a condition, such as heart or lung disease, that preclude safely engaging in physical activity 6. Have received a solid organ transplant 7. Have limited English proficiency 8. Are on dialysis 9. In the opinion of the investigator, are unable to comply with the requirements of the study protocol or are unsuitable for the study for any reason For caregivers participants: 1\. Limited English proficiency
Where it's running
-
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Amy Kogon, MD MPH — Children's Hospital of Philadelphia
- Study coordinator: Jillian LoGuidice, BS
- Email: loguidicej@chop.edu
- Phone: 267-425-4541
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes
This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.
-
Impact of TAVR on kidney function in people with aortic valve disease
This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.
-
Calciphylaxis in people with chronic kidney disease: causes, risks, and early signs
This project will compare adults with chronic kidney disease who develop calciphylaxis to matched CKD patients who do not, collecting clinical data and biological samples to try to find risk factors and early signs.
-
Oral Semaglutide for CKD and MAFLD in adults with diabetes
This study tests whether adding oral semaglutide to standard care can slow kidney and liver disease progression in adults with CKD and MAFLD who have type 2 diabetes.
-
Eye-brain-kidney connections in chronic kidney disease
This study will see if changes in brain network connectivity and retinal blood vessels are linked to cognitive decline and kidney function in adults with chronic kidney disease.
-
Screening for chronic kidney disease
We will see how common chronic kidney disease is among adults followed at a tertiary care center and how many cases were previously undiagnosed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.