Improving Vitamin D Levels with Different Treatments
Official title: Different Kinds of Vitamin D Intake and Its Metabolites: Blood Levels and Bone Mineral Density. A Randomized Clinical Trial.
Run by Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari · NCT06138249 · Data updated 2026-11-12
This study is testing which of two types of Vitamin D supplements works best for people with low Vitamin D levels to help improve their health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari Academic / other |
| Locations | 1 site (Bari) |
| Status | Recruiting |
| Started | July 1, 2023 |
| Main results expected | December 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | November 25, 2025 |
| Trial ID | NCT06138249 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with hypovitaminosis D, characterized by serum levels below 20 ng/mL.
✕Probably not a fit
Patients with osteoporosis or those suffering from renal or hepatic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of two forms of Vitamin D supplementation, Calcifediol and Cholecalciferol, in patients suffering from hypovitaminosis D. Participants are randomly assigned to one of three treatment groups: one receiving Calcifediol monthly, another receiving Cholecalciferol bi-weekly, and a third receiving daily Calcifediol drops. After one month of treatment, serum levels of Vitamin D will be measured to determine the most effective dosage. The study aims to optimize Vitamin D intake for better health outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved Vitamin D levels in patients, enhancing their overall health and well-being.
How similar studies have gone: Other studies have shown varying success with Vitamin D supplementation, but this specific comparison of Calcifediol and Cholecalciferol is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hypovitaminosis D (\<20ng/mL) Exclusion Criteria: * Osteoporosis (T score \<-2.5SD) * Renal or hepatic diseases
Where it's running
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University of Bari
Bari, Italy Recruiting
Study contacts
- Study coordinator: Silvana De Giorgi, AP
- Email: silvana.degiorgi@uniba.it
- Phone: 3389821930
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Vitamin D3 and K2 for healthcare personnel
This study tests whether daily vitamin D3 and/or K2 supplements or a placebo change blood vitamin levels and the gut microbiome in military healthcare personnel with low vitamin D.
-
Bone health, vitamin D, weight, and fractures in children
See if blood markers (alkaline phosphatase, calcium, PTH, vitamin D), body weight, and calcium intake are linked to fractures in children aged 3–15 after low-energy trauma.
-
Vitamin D3 effects on brain waves in men with epilepsy and low vitamin D
This will test whether taking high‑dose vitamin D3 weekly for 8 weeks changes brain wave patterns in men (age 20–40) who have epilepsy and low vitamin D levels.
-
San Raffaele registry of adults receiving vitamin D treatment
This project will see how vitamin D supplements are used and affect adults with low vitamin D who attend the San Raffaele outpatient clinic.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.