Vitamin D3 effects on brain waves in men with epilepsy and low vitamin D
Official title: Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D: A Quantitative Electroencephalogram Analysis
Run by Bangladesh Medical University · NCT07096414 · Data updated 2026-11-12
This will test whether taking high‑dose vitamin D3 weekly for 8 weeks changes brain wave patterns in men (age 20–40) who have epilepsy and low vitamin D levels.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 40 Years |
| Sex | Men only |
| Enrollment | 15 (estimated) |
| Sponsor | Bangladesh Medical University Academic / other |
| Locations | 1 site (Dhaka, Shahbag, Dhaka) |
| Status | Recruiting |
| Started | July 19, 2025 |
| Main results expected | October 2025 |
| Study ends | October 2025 |
| Registry record updated | July 31, 2025 |
| Trial ID | NCT07096414 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men aged 20–40 with a neurologist‑diagnosed epilepsy, BMI 20–24 kg/m², on enzyme‑inducing AEDs for 6 months–2 years, and with serum 25(OH)D <30 ng/mL, who are otherwise medically well, are ideal candidates.
✕Probably not a fit
Patients with absence seizures, those taking excluded AEDs (e.g., valproate, levetiracetam, lamotrigine), smokers, heavy alcohol users, or people with hypertension, thyroid disease, diabetes, or renal disease are excluded and unlikely to benefit from these specific results.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single‑site, self‑controlled pretest–posttest interventional trial enrolling 15 men with epilepsy, BMI 20–24 kg/m², on enzyme‑inducing antiepileptic drugs and with serum 25(OH)D <30 ng/mL. Baseline serum 25(OH)D and quantitative EEG (QEEG) band power (delta, theta, alpha, beta) will be recorded, then participants will receive oral vitamin D3 50,000 IU once weekly for 8 weeks. After 8 weeks the serum 25(OH)D and QEEG will be repeated and changes in band power will be compared within each participant. EEG data will be collected using the EEG Traveler BrainTech 32+ CMEEG-01 device and analyzed with BT40 software, and the study is conducted at Bangladesh Medical University in Dhaka.
Why it matters
Potential benefit: If successful, correcting vitamin D deficiency could improve brain electrical activity in men with epilepsy and suggest a simple adjunctive approach to support neurological health.
How similar studies have gone: Some observational and mechanistic studies suggest vitamin D can affect neuronal excitability and seizure risk, but randomized or QEEG‑focused trials are limited and results are mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed male patients with Epilepsy by neurologist from the Out Patient Department of Department of Neurology, BMU by taking proper history of at least two unprovoked (or reflex) seizures occurring \> 24 hours apart, from patients and eye witnesses. * Hypovitaminosis D (\<30 ng/ml) * BMI : 20 - 24 kg/m² * On antiepileptic medication for 6 months to 2 years (enzyme inducing AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital) * Without any medication that affect central nervous system other than antiepileptic drugs (Antidepressants, Antipsychotic, Anxiolytic, Anesthetic drugs) * Apparently normal physical health Exclusion Criteria: * Patients suffering from absence seizure * Certain AEDs (Sodium valproate, Ethosuximide, Oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam) * Smoker * Alcoholic * Known hypersensitivity to vitamin D3 * Patients with hypertension * Patient with Thyroid disorder * Patient with Diabetes mellitus * Patient with Renal Disease * Patient with liver Disease * Patient with hypercalcemia
Where it's running
-
Bangladesh Medical University
Dhaka, Shahbag, Dhaka, Bangladesh Recruiting
Study contacts
- Principal investigator: Dr.Sumayya Binte Abdur Razzaque, MBBS, MD Resident (Phase B) — Bmu
- Study coordinator: Registrar, BMU
- Email: registrar@bsmmu.edu.bd
- Phone: +88 02 55165708
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.