Improving vascular health in patients with hypertension through medication and exercise
Official title: Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.
Run by Heinrich-Heine University, Duesseldorf · NCT06823570 · Data updated 2026-11-12
This study is testing whether a combination of blood pressure medication and personalized exercise can help people with high blood pressure improve their heart and blood vessel health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Heinrich-Heine University, Duesseldorf Academic / other |
| Locations | 1 site (Düsseldorf, Düsseldorf) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | May 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | March 12, 2025 |
| Trial ID | NCT06823570 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with grade I-II systolic hypertension who are not currently on anti-hypertensive medication.
✕Probably not a fit
Patients with isolated diastolic hypertension, chronic eye diseases, or medical contraindications for exercise treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of anti-hypertensive medication combined with individualized exercise training on blood pressure and vascular health in patients with hypertension. It aims to understand the mechanisms that contribute to vascular health by analyzing changes in metabolism and cell function. The study will involve 60 patients who have not previously received anti-hypertensive treatment, with regular assessments of blood pressure and vascular function over one year. The goal is to determine the effectiveness of these interventions in improving vascular health and identifying sensitive biomarkers for therapy-induced adaptations.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for hypertension, enhancing vascular health and reducing related complications.
How similar studies have gone: Previous studies have shown that exercise interventions can improve vascular dysfunction in hypertensive patients, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- systolic hypertension grade I-II (BP values \>140 mmHg to \<180 mmHg) without anti-hypertensive medication treatment Exclusion Criteria: * no written informed consent * age \<18 years * isolated diastolic hypertension * medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test) * chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\>20 mmHg)
Where it's running
-
Universitätsklinik Düsseldorf
Düsseldorf, Düsseldorf, Germany Recruiting
Study contacts
- Study coordinator: Johannes Stegbauer, Prof. Dr.
- Email: Studienzentrum-Nephrologie@med.uni-duesseldorf.de
- Phone: +49 211 81 080 74
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.