Improving vascular health in patients with hypertension through medication and exercise
Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.
NA · Heinrich-Heine University, Duesseldorf · NCT06823570
This study is testing whether a combination of blood pressure medication and personalized exercise can help people with high blood pressure improve their heart and blood vessel health.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Heinrich-Heine University, Duesseldorf (other) |
| Locations | 1 site (Düsseldorf, Düsseldorf) |
| Trial ID | NCT06823570 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of anti-hypertensive medication combined with individualized exercise training on blood pressure and vascular health in patients with hypertension. It aims to understand the mechanisms that contribute to vascular health by analyzing changes in metabolism and cell function. The study will involve 60 patients who have not previously received anti-hypertensive treatment, with regular assessments of blood pressure and vascular function over one year. The goal is to determine the effectiveness of these interventions in improving vascular health and identifying sensitive biomarkers for therapy-induced adaptations.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with grade I-II systolic hypertension who are not currently on anti-hypertensive medication.
Not a fit: Patients with isolated diastolic hypertension, chronic eye diseases, or medical contraindications for exercise treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for hypertension, enhancing vascular health and reducing related complications.
How similar studies have performed: Previous studies have shown that exercise interventions can improve vascular dysfunction in hypertensive patients, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- systolic hypertension grade I-II (BP values \>140 mmHg to \<180 mmHg) without anti-hypertensive medication treatment Exclusion Criteria: * no written informed consent * age \<18 years * isolated diastolic hypertension * medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test) * chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\>20 mmHg)
Where this trial is running
Düsseldorf, Düsseldorf
- Universitätsklinik Düsseldorf — Düsseldorf, Düsseldorf, Germany (RECRUITING)
Study contacts
- Study coordinator: Johannes Stegbauer, Prof. Dr.
- Email: Studienzentrum-Nephrologie@med.uni-duesseldorf.de
- Phone: +49 211 81 080 74
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypertension, Vascular Function, Fitness Testing, Metabolism Changes, cardiorespiratory fitness, retinal microcirculation, endothelial function, exercise training