Improving treatment for patients with borderline personality disorder
PEGASUS - Improving Treatment for Patients With Emotionally Unstable Personality Disorder
This study is testing a new treatment approach for people with borderline personality disorder to see if adding case management and family meetings helps them feel better compared to standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Bispebjerg and Frederiksberg Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06563466 on ClinicalTrials.gov |
What this trial studies
The PEGASUS intervention aims to enhance treatment for individuals with emotionally unstable personality disorder, specifically borderline personality disorder, by integrating case management and family-based meetings into existing psychiatric care models in Denmark. This pilot trial will compare the PEGASUS intervention to standard treatment, assessing feasibility and acceptability through a randomized, assessor-blinded parallel-groups design. Participants will be evaluated at baseline and again nine months later to determine the effectiveness of the intervention in improving patient outcomes.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are newly accepted into BPD treatment packages and can involve family members or close friends.
Not a fit: Patients with a primary diagnosis of schizophrenia or those with substance abuse issues may not benefit from this intervention.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the quality of life and treatment outcomes for patients with borderline personality disorder.
How similar studies have performed: Previous studies have shown promise in integrating family involvement in the treatment of borderline personality disorder, suggesting that this approach may be beneficial.
Eligibility criteria
Show full inclusion / exclusion criteria
Participating Patients
Inclusion Criteria:
* Must be able to give an informed written consent.
* Must be newly accepted in the pre-planned BPD treatment packages.
* ≥18 years of age.
* Agreeing to involvement of one or two informal caregivers, families, or close friends ("Relatives").
* Capable of reading and understanding Danish.
Exclusion Criteria:
* None\*
* Note that to get accepted into a treatment package for BPD, patients must not fulfill the criteria for a F20 diagnosis or the criteria for alcohol or substance abuse or harmful use.
Participating Relatives:
Inclusion Criteria:
* Must be able to give an informed written consent.
* ≥18 years of age.
* Capable of reading and understanding Danish.
Exclusion criteria: None
Where this trial is running
Copenhagen
- Copenhagen Research Center for Mental Health - CORE — Copenhagen, Denmark (Recruiting)
Study contacts
- Principal investigator: Carsten Hjorthøj, Ph.d. — Copenhagen Research Center for Mental Health
- Study coordinator: Ditte H. Rotvig, MD
- Email: ditte.hoeyer.rotvig@regionh.dk
- Phone: +45 31154887
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.