Improving treatment for patients with borderline personality disorder
Official title: PEGASUS - Improving Treatment for Patients With Emotionally Unstable Personality Disorder
Run by University Hospital Bispebjerg and Frederiksberg · NCT06563466 · Data updated 2026-11-12
This study is testing a new treatment approach for people with borderline personality disorder to see if adding case management and family meetings helps them feel better compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital Bispebjerg and Frederiksberg Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | October 31, 2027 |
| Study ends | August 31, 2029 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT06563466 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older who are newly accepted into BPD treatment packages and can involve family members or close friends.
✕Probably not a fit
Patients with a primary diagnosis of schizophrenia or those with substance abuse issues may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PEGASUS intervention aims to enhance treatment for individuals with emotionally unstable personality disorder, specifically borderline personality disorder, by integrating case management and family-based meetings into existing psychiatric care models in Denmark. This pilot trial will compare the PEGASUS intervention to standard treatment, assessing feasibility and acceptability through a randomized, assessor-blinded parallel-groups design. Participants will be evaluated at baseline and again nine months later to determine the effectiveness of the intervention in improving patient outcomes.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the quality of life and treatment outcomes for patients with borderline personality disorder.
How similar studies have gone: Previous studies have shown promise in integrating family involvement in the treatment of borderline personality disorder, suggesting that this approach may be beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Participating Patients
Inclusion Criteria:
* Must be able to give an informed written consent.
* Must be newly accepted in the pre-planned BPD treatment packages.
* ≥18 years of age.
* Agreeing to involvement of one or two informal caregivers, families, or close friends ("Relatives").
* Capable of reading and understanding Danish.
Exclusion Criteria:
* None\*
* Note that to get accepted into a treatment package for BPD, patients must not fulfill the criteria for a F20 diagnosis or the criteria for alcohol or substance abuse or harmful use.
Participating Relatives:
Inclusion Criteria:
* Must be able to give an informed written consent.
* ≥18 years of age.
* Capable of reading and understanding Danish.
Exclusion criteria: None
Where it's running
-
Copenhagen Research Center for Mental Health - CORE
Copenhagen, Denmark Recruiting
Study contacts
- Principal investigator: Carsten Hjorthøj, Ph.d. — Copenhagen Research Center for Mental Health
- Study coordinator: Ditte H. Rotvig, MD
- Email: ditte.hoeyer.rotvig@regionh.dk
- Phone: +45 31154887
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Long-term outcomes after MBT for borderline personality disorder
This long-term follow-up checks how people with borderline personality disorder who received MBT in the past are doing more than 10 years later and whether the two MBT formats differ in long-term outcomes.
-
See if Borderline Personality Disorder can be viewed as a Relationship-Use Disorder
Researchers are testing whether BPD symptoms reflect an addiction-like reliance on interpersonal relationships, compared with bipolar disorder and healthy controls.
-
rTMS (noninvasive brain stimulation) for borderline personality disorder
This project will try rTMS brain stimulation to see if it reduces symptoms in adults with borderline personality disorder.
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Evaluating a new treatment approach for borderline personality disorder
This study is testing a new personalized treatment for borderline personality disorder to see if it works better than the standard approach.
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Physical activity for people with schizophrenia, borderline personality disorder, or vestibular disorders
This study tests whether a tailored physical activity program helps people with schizophrenia, borderline personality disorder, or vestibular disorders improve activity adherence and well‑being.
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Training to improve emotion regulation in people with Borderline Personality Disorder
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.