Improving treatment for ischemic stroke with poor blood flow after thrombectomy
Official title: Improving Neuroprotective Strategy for Ischemic Stroke With Poor Recanalization After Thrombectomy by Intra-arterial TNK (INSIST-TNK): a Prospective, Single Arm, Pilot Study
Run by General Hospital of Shenyang Military Region · NCT04201964 · Data updated 2026-11-12
This study is testing whether giving a medication called tenecteplase after a procedure to remove a blood clot can help improve blood flow in stroke patients who didn't get enough recovery from the treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | General Hospital of Shenyang Military Region Academic / other |
| Locations | 1 site (Shenyang) |
| Status | Recruiting |
| Started | December 15, 2019 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT04201964 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have experienced an acute ischemic stroke with a large vessel occlusion and have insufficient perfusion after thrombectomy.
✕Probably not a fit
Patients who achieve sufficient recanalization after thrombectomy or have contraindications such as severe hemorrhagic conditions will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of intra-arterial tenecteplase in patients who have undergone thrombectomy for acute ischemic stroke but have not achieved sufficient blood flow restoration. It aims to determine the proportion of patients who achieve adequate recanalization after receiving tenecteplase, a thrombolytic agent, following thrombectomy. The study builds on previous findings that suggest tenecteplase may lead to better outcomes compared to alteplase when administered before thrombectomy. By focusing on patients with insufficient recanalization, this research seeks to provide new insights into improving treatment strategies for ischemic stroke.
Why it matters
Potential benefit: If successful, this approach could enhance recovery outcomes for patients with ischemic stroke who do not achieve sufficient blood flow restoration after thrombectomy.
How similar studies have gone: Previous studies have shown promising results with similar approaches, indicating potential for success in this novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥18 years; 2. Patients who presented with acute ischemic stroke and a large vessel occlusion in the anterior circulation and met the criteria of mechanical thrombectomy; 3. insufficient perfusion (mTICI 1/2a) after endovascular treatment; 4. The availability of informed consent. Exclusion Criteria: 1. Sufficient recanalization (TICI 2b-3); 2. More than 3 times of thrombectomy device passes 3. Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage 4. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia ( \<100000/mm3) 5. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis 6. Severe uncontrolled hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg) 7. Patients allergic to any ingredient of drugs in our study 8. Unsuitable for this clinical studies assessed by researcher
Where it's running
-
General Hospital of Northern Theater Command
Shenyang, China Recruiting
Study contacts
- Study coordinator: Zi-Ai Zhao, Doctor
- Email: zhaoziai@hotmail.com
- Phone: +86 17790998175
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Remote ischemic conditioning for post-stroke insomnia
A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.
-
Ear-based nerve stimulation to help sleep after a stroke
A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.
-
Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)
This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
-
Preventing another ischemic stroke with a smart bracelet and app
This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.
-
Photon-counting CT to check intracranial stents
This study tests whether ultra-high-resolution photon-counting CT can reliably visualize intracranial stents and detect in-stent restenosis during follow-up of patients with prior stents.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.