Improving respiratory muscle training for patients weaning off mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of different inspiratory muscle training (IMT) regimens on respiratory muscle function in patients who are being weaned from mechanical ventilation in the ICU. It aims to address the common issue of respiratory muscle weakness that can prolong mechanical ventilation and increase mortality rates. Participants will be exposed to three different training conditions, including usual care, high-intensity IMT, and low-intensity sham IMT, to evaluate their physiological responses. The study seeks to provide a better understanding of the optimal approach to IMT for improving weaning outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Difficult and prolonged weaning patients
* Adequate oxygenation
* Febrile temperature \< 38ºC
* Hemodynamic stability
* Stable blood pressure
* No or minimal vasopressors
* No myocardial ischemia
* Adequate hemoglobin and mentation
* Resolution of disease acute phase
* Able to follow simple verbal commands related to IMT
* Mechanically ventilated via a tracheostomy or endotracheal tube

Exclusion Criteria:

* Pre-existing neuromuscular disease
* Agitation
* Hemodynamically instable (arrhythmia, decompensated heart failure, coronary insufficiency)
* Hemoptysis
* Diaphoresis
* Spinal cord injury above T8
* Use of any type of home MV support prior to hospitalization
* Skeletal pathology that impairs chest wall movements
* Poor general prognosis or fatal outcome

Where it's running

• University Hospital Leuven
  Leuven, Belgium Recruiting

Study contacts

• Study coordinator: Daniel Langer, PT, PhD
• Email: daniel.langer@kuleuven.be
• Phone: +3216330192

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.