Improving recruitment for stroke rehabilitation trials in Canada

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot project aims to enhance recruitment for stroke rehabilitation trials by developing a women-centered and aphasia-friendly approach. It will assess the feasibility of using a video and leaflet to support traditional recruitment methods, focusing on underrepresented groups such as women and individuals with aphasia. The study will also explore barriers and facilitators to participation in stroke recovery trials and provide preliminary estimates of the effectiveness of the new recruitment strategy compared to standard methods. The research will be conducted across multiple sites in Canada.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Primary ischemic anterior circulation stroke
2. Age ≥18 years
3. ≥5 days but \<8 weeks after stroke on the date of medication (Maraviroc or placebo) start
4. Hemiparesis requiring inpatient rehabilitation
5. Assistance available for daily rehabilitation training practice and for transportation when needed
6. Adequate language skills to understand Informed Consent and retain information during daily therapies
7. At least one of the following: some shoulder abduction with gravity eliminated and visible extension in two or more digits OR visible hip flexion or extension

Exclusion Criteria:

1. Pre-stroke modified Rankin score ≥2
2. Limited resources or illness that will not enable a return to living outside of a facility
3. History of dementia
4. History of hepatitis or elevated hepatic transaminases or bilirubin
5. History of renal insufficiency or creatinine clearance (eGFR) \<60mL / min / 1.73m2
6. Cancer or other chronic illness that makes 1-year survival unlikely or will detract from the ability to carry out exercise and skills practice
7. Existing pre-stroke serious disabling disease (e.g., Parkinson's disease, severe traumatic brain injury, amputation)
8. Seizure related to stroke
9. Acute or chronic epilepsy
10. Currently taking any of the following anticonvulsant medications: Carbamazepine, Phenobarbital, Phenytoin
11. Pregnant, breastfeeding, or positive test for pregnancy at baseline
12. Women of childbearing potential who are not using one highly effective form of contraception or two forms of effective contraception
13. Known HIV positivity
14. Currently taking any of the following antifungal and/or antibacterial medications: Ketoconazole, Itraconazole, Voriconazole, Rifampin, Clarithromycin, Rifabutin + Protease Inhibitor
15. Currently taking St. John's Wort

Where it's running

• University of Calgary & Foothills Medical Centre
  Calgary, Alberta, Canada Recruiting
• University of British Columbia & GF Strong Rehabilitation Centre
  Vancouver, British Columbia, Canada Recruiting
• Dalhousie University
  Halifax, Nova Scotia, Canada Recruiting
• Parkwood Institute
  London, Ontario, Canada Recruiting
• Toronto Rehabilitation Institute - University Health Network
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Study coordinator: Ada Tang, PT PhD
• Email: atang@mcmaster.ca
• Phone: 289-426-5768

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Dual-task balance training plus computer-based cognitive training after stroke

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.