Improving radiation protection using genomic analysis
Optimization of Radiation Protection Through Genomic Analyses in the Analysis of Changes in Cells of the Hematopoietic System Before and During High Dose External Beam Radiotherapy
This study is testing if analyzing DNA changes in blood samples can help us understand how some people are better at handling radiation exposure than others.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Essen Academic / other |
| Drugs / interventions | chemotherapy, radiation, immunotherapy |
| Locations | 1 site (Essen, Germany / NRW) |
| Trial ID | NCT06253338 on ClinicalTrials.gov |
What this trial studies
This study aims to identify genomic signatures that indicate radiation exposure and repair capacity in individuals. By utilizing Next Generation Sequencing (NGS) methods, researchers will analyze DNA changes in human lymphocytes caused by different types of radiation. The study will focus on understanding how these genomic alterations relate to radiation resistance and the effectiveness of repair pathways. Participants will voluntarily donate blood samples, and only those without prior cancer diagnoses or treatments will be included.
Who should consider this trial
Good fit: Ideal candidates are individuals with thoracic or head and neck cancer who have not undergone any prior cancer treatments.
Not a fit: Patients with a history of cancer treatment or previous cancer diagnoses will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could enhance radiation protection strategies and improve patient outcomes in cancer treatment.
How similar studies have performed: While genomic analysis in radiation research is a growing field, this specific approach focusing on lymphocytes and radiation signatures is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: ECOG 0/1 no prior treatment no prior cancer diagnosis thoracic or head and neck cancer Exclusion Criteria: prior treatment (chemotherapy, radiotherapy, etc.) prior cancer diagnosis
Where this trial is running
Essen, Germany / NRW
- Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West — Essen, Germany / NRW, Germany (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.