Improving radiation protection using genomic analysis
Official title: Optimization of Radiation Protection Through Genomic Analyses in the Analysis of Changes in Cells of the Hematopoietic System Before and During High Dose External Beam Radiotherapy
Run by University Hospital, Essen · NCT06253338 · Data updated 2026-11-12
This study is testing if analyzing DNA changes in blood samples can help us understand how some people are better at handling radiation exposure than others.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University Hospital, Essen Academic / other |
| Drugs / interventions | chemotherapy, radiation, immunotherapy |
| Locations | 1 site (Essen, Germany / NRW) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | December 15, 2027 |
| Study ends | January 15, 2030 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT06253338 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with thoracic or head and neck cancer who have not undergone any prior cancer treatments.
✕Probably not a fit
Patients with a history of cancer treatment or previous cancer diagnoses will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to identify genomic signatures that indicate radiation exposure and repair capacity in individuals. By utilizing Next Generation Sequencing (NGS) methods, researchers will analyze DNA changes in human lymphocytes caused by different types of radiation. The study will focus on understanding how these genomic alterations relate to radiation resistance and the effectiveness of repair pathways. Participants will voluntarily donate blood samples, and only those without prior cancer diagnoses or treatments will be included.
Why it matters
Potential benefit: If successful, this research could enhance radiation protection strategies and improve patient outcomes in cancer treatment.
How similar studies have gone: While genomic analysis in radiation research is a growing field, this specific approach focusing on lymphocytes and radiation signatures is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: ECOG 0/1 no prior treatment no prior cancer diagnosis thoracic or head and neck cancer Exclusion Criteria: prior treatment (chemotherapy, radiotherapy, etc.) prior cancer diagnosis
Where it's running
-
Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West
Essen, Germany / NRW, Germany Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.