Improving physical health and lifestyle in patients with severe mental illness using an eHealth intervention

Improving Physical Health and Lifestyle Behaviors in Patients With Serious Mental Illness: a Cluster Randomized Controlled Trial on the Effectiveness of the Nurse-led GILL eHealth Intervention

Not applicable Interventional Amsterdam UMC, location VUmc · NCT05533749

This study is testing whether a nurse-led eHealth program can help adults with severe mental illness improve their physical health and lifestyle compared to regular care.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment258 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorAmsterdam UMC, location VUmc Academic / other
Locations1 site (The Hague, South Holland)
Trial IDNCT05533749 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of the GILL eHealth intervention, which is nurse-led, in enhancing physical health and lifestyle behaviors among patients with severe mental illness. It involves a cluster randomized controlled trial comparing the GILL intervention to usual care. The intervention includes somatic screening and lifestyle promotion, resulting in personalized treatment and lifestyle plans for participants. A total of 258 adult patients with a body mass index of 27 or higher will be included, and trained mental health nurses will guide the patients throughout the process.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 65 with severe mental illness and a body mass index of 27 or higher who can access and use the internet.

Not a fit: Patients experiencing acute psychiatric crises, severe somatic diseases, or cognitive impairments that hinder participation may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the physical health and lifestyle behaviors of patients with severe mental illness.

How similar studies have performed: Other studies have shown promise in using eHealth interventions for improving health outcomes in similar populations, suggesting this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Meet the criteria of severe mental illness
* Aged from 18 to 65 years
* Body mass index (BMI) ≥ 27
* Access and ability to use internet
* Able and willing to sign informed consent

Exclusion Criteria:

* Contra-indications (to be assessed by the treating physician/psychiatrist) for participation due to acute psychiatric crisis or severe somatic diseases
* Subjects with a cognitive impairment sufficient to interfere with their ability to provide informed consent, complete study questionnaires, or participate in the intervention
* Pregnant or breastfeeding women at the time of inclusion
* Subject not able to communicate in the Dutch language

Where this trial is running

The Hague, South Holland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Severe Mental DisorderMetabolic SyndromeLifestyleSomatic ScreeningeHealth
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.