Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Improving oral care to prevent pneumonia in COPD patients in the ICU

Official title: Routine Oral Care Versus Chlorhexidine Oral Care on Incidence of Nosocomial Pneumonia and Oral Health Among Critically Ill Non-intubated Patients With COPD

Run by Assiut University · NCT06691399 · Data updated 2026-11-12

This study is testing if better oral care can help prevent pneumonia in COPD patients who are in the ICU.

More COPD Exacerbation trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorAssiut University
Academic / other
Locations1 site (Asyut)
StatusRecruiting
StartedOctober 1, 2024
Main results expectedApril 1, 2025
Study endsJune 1, 2025
Registry record updatedNovember 15, 2024
Trial IDNCT06691399 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are COPD patients who are admitted to the ICU with acute exacerbations and require noninvasive ventilatory support.

Probably not a fit

Patients with end-stage organ failure or those who refuse to participate may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of enhanced oral care on the prevention of nosocomial pneumonia in patients with Chronic Obstructive Pulmonary Disease (COPD) who are admitted to the ICU. It focuses on the relationship between poor dental hygiene and the colonization of respiratory pathogens in the oral cavity, which can lead to pneumonia. By implementing oral care interventions, the study aims to reduce the incidence of pneumonia and improve patient outcomes in critical care settings. The methodology includes assessing the oral hygiene practices and monitoring the development of pneumonia in participating patients.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of pneumonia in ICU patients with COPD, leading to improved survival rates and reduced healthcare costs.

How similar studies have gone: While the specific approach of this study may be novel, previous studies have indicated that improving oral hygiene can reduce the risk of pneumonia in ICU settings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients diagnosed as COPD
* admitted to ICU with acute exacerbation
* need for noninvasive ventilatory support including noninvasive ventilation anf high flow nasal cannula

Exclusion Criteria:

* patients refusing to participate
* End stage organ failure (Heart Failure, Liver cell failure and/or Renal failure

Where it's running

  • Faculty of Medicine, Assiut University
    Asyut, Egypt
    Recruiting

Study contacts

  • Principal investigator: Waleed MD Gamal Elddin Khaleel, Ass. Prof. — Assiut University
  • Study coordinator: Waleed MD Gamal Elddin Khaleel, Ass. Prof.
  • Email: waleed_gamal@aun.edu.eg
  • Phone: +201006519722

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.