Improving muscle repair after knee surgery
Regulation of Protein Turnover in Connective Tissue From Muscle and Tendon Following Muscle Tissue Injury
This study is testing if giving growth hormone or a placebo, along with electrical stimulation of the hamstring muscles, can help patients recover better after knee surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Bispebjerg Hospital Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT05746650 on ClinicalTrials.gov |
What this trial studies
This study involves 40 patients scheduled for reconstructive knee surgery who will be randomized to receive either growth hormone or a placebo, with or without neuromuscular electrical stimulation of the hamstring muscles. The primary goal is to assess the impact of these interventions on muscle connective tissue protein synthesis and its role in muscle injury and repair. The study will last for two weeks and aims to provide insights into enhancing recovery following muscle injuries.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women with a BMI between 18 and 35 who are scheduled for reconstructive knee surgery.
Not a fit: Patients with a history of growth hormone or anabolic steroid use, chronic diseases, or those taking medications affecting muscle turnover may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery outcomes for patients undergoing knee surgery by enhancing muscle repair processes.
How similar studies have performed: While there is ongoing research in muscle repair, this specific approach combining growth hormone and electrical stimulation is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy men and women scheduled to undergo reconstructive knee surgery * BMI 18-35 Exclusion Criteria: * Former or current use of growth hormone or anabolic steroids * Use of corticosteroids in the past 3 months * Use of any medication known to affect muscle or tendon turnover * Former participation in a study using deuterated water * Chronic diseases
Where this trial is running
Copenhagen
- Bispebjerg Hospital — Copenhagen, Denmark (Recruiting)
Study contacts
- Principal investigator: Grith Højfeldt, PhD — Institute of Sports Medicine, Bispebjerg Hospital
- Study coordinator: Grith Stougaard Højfeldt, PhD
- Email: grith.stougaard.hoejfeldt@regionh.dk
- Phone: +45 61651061
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.