Multimodal Laser Treatment for Photodamaged Facial Skin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized study assigns one side of the face to a multimodal treatment using a 1927-nm thulium laser, a 1550-nm non-ablative fractional laser, and IPL, while the other side remains untreated. Participants are followed for 14 months to evaluate changes in photodamage and the potential longer-term preventive effects. The trial also aims to explore how these treatments affect the biology of chronically sun-damaged skin. Enrollment is limited to adults with facial photodamage and low-grade actinic keratosis, and several exclusion criteria limit participation to those without conflicting skin conditions or recent cosmetic procedures. Outcomes include clinical efficacy and exploratory insights into cancer-prevention potential.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Clinical signs of facial photodamage, including low-grade actinic keratosis (Olsen grade I-II) , solar lentigines, mottled hyper- and hypopigmentation, telangiectasia, skin thinning or atrophy, loss of skin elasticity (solar elastosis), coarse, leathery texture

Exclusion Criteria:

* Fitzpatrick skin type ≥ 4
* Active skin disease in the treatment area that may interfere with study treatment or assessments
* Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments
* Pregnancy or breastfeeding
* Contraindications to the three lasers or topical anesthetics
* Fitzpatrick skin type ≥ 4
* Active skin disease in the treatment area that may interfere with study treatment or assessments
* Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments
* Pregnancy or breastfeeding
* Contraindications to the three lasers or topical anesthetics

Where it's running

• Department of Dermatology, Bispebjerg Hospital
  Copenhagen NV, Denmark Recruiting

Study contacts

• Study coordinator: Aqella Rasul, MD
• Email: aqella.rasul.01@regionh.dk
• Phone: 0045 71590063

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.