Improving mental health for young people at risk of psychosis
Optimizing Mental Health for Young People at Clinical High Risk for Psychosis (CHR)
This study is testing a 12-week mental health program for young people aged 16-29 who are at risk of developing psychosis to see if it can help them feel better and function well.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 16 Years to 29 Years |
| Sex | All |
| Sponsor | Centre for Addiction and Mental Health Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT05757128 on ClinicalTrials.gov |
What this trial studies
This study aims to adapt the Optimal Health Program (OHP), a comprehensive psychosocial and mental health support program, for young individuals aged 16-29 who are at clinical high risk for developing psychosis. The intervention will be delivered over a 12-week period, focusing on enhancing resiliency, reducing symptoms of depression and anxiety, and improving overall functioning. The study will evaluate the acceptability and feasibility of the OHP, as well as its preliminary efficacy through a single-arm exploratory clinical trial. Participants will complete assessments at the beginning and end of the intervention to measure outcomes.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 16-29 who meet the criteria for clinical high risk for psychosis.
Not a fit: Patients with a diagnosed psychotic disorder or severe developmental disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly improve mental health outcomes and functioning for young people at risk of psychosis.
How similar studies have performed: Other studies have shown success with psychosocial interventions for mental health, making this approach promising yet still exploratory.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Be 16-29 years old 2. Being competent and willing to consent to study participation 3. Meets CHR criteria for a psychosis risk syndrome based on the Structured Interview for Psychosis Risk Syndromes (SIPS) either currently or at some point in the past 3 years. Exclusion Criteria: 1. Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of psychotic disorder (e.g., schizophrenia spectrum disorder, mood disorder with psychotic features) 2. Diagnosis of intellectual disability previously documented in the patient chart 3. Severe developmental disorder 4. Acute suicidality requiring immediate intervention
Where this trial is running
Toronto, Ontario
- Center for Addiction and Mental Health — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Omair Husain, MBBS — center of addiction and mental health
- Study coordinator: Omair Husain, MBBS
- Email: omair.husain@camh.ca
- Phone: (416) 535-8501
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.