Improving HPV vaccination rates through financial incentives

The Impact of Clinic-level Financial Incentives on HPV Vaccine Communication and Uptake

Not applicable Interventional UNC Lineberger Comprehensive Cancer Center · NCT05744960

This study is testing if giving clinics financial rewards and communication training can help them get more kids aged 9-12 vaccinated against HPV.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment34 (estimated)
Ages9 Years to 12 Years
SexAll
SponsorUNC Lineberger Comprehensive Cancer Center Academic / other
Locations1 site (Chapel Hill, North Carolina)
Trial IDNCT05744960 on ClinicalTrials.gov

What this trial studies

This trial investigates the effectiveness of clinic-level financial incentives combined with communication training to enhance provider communication and increase HPV vaccine uptake among children aged 9-12. A total of 34 clinics in North Carolina will be randomly assigned to either receive communication training alone or both training and financial incentives, with the latter group also receiving monthly data feedback reports. The study will track vaccination rates over a 24-month period using medical record data to assess the impact of these interventions on HPV vaccination rates. The focus is on pediatric and family medicine clinics that have previously struggled with low vaccination rates.

Who should consider this trial

Good fit: Ideal candidates for this study are pediatric and family medicine clinics in North Carolina with low HPV vaccination initiation rates.

Not a fit: Patients who are not part of the clinics involved in the study or those who are not within the targeted age range of 9-12 years will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly increase HPV vaccination rates among children, leading to better prevention of HPV-related diseases.

How similar studies have performed: Previous studies have shown that financial incentives can improve vaccination rates, suggesting that this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria
This trial will enroll clinics and intervene with clinical staff. We will use vaccination data from children to evaluate intervention effectiveness. We will not enroll children or interact with them directly.

Inclusion Criteria:

Clinics are eligible if they are a pediatric or family medicine clinic in North Carolina that in the past year had:

* less than 72% HPV vaccine initiation rate,
* greater than or equal to 50 patients ages 9-12
* greater than or equal to 2 HPV vaccine providers
* no clinic or provider-level financial incentive programs to increase system, clinic, or provider HPV vaccination rates among patients aged 9-12 in the past two years, and
* no HPV vaccine provider communication trainings in the past six months.

Children's medical records will be eligible to be included in the dataset if children:

* are between the ages of 9-12 years at baseline and
* are attributed to a participating clinic at 12- or 24-month follow-up.

Exclusion Criteria:

Clinics are excluded if they:

* do not provide HPV vaccine to children ages 9-12
* have a specialty other than pediatrics or family medicine
* had an HPV vaccine-specific financial incentive program in the past two years
* had a formal HPV vaccine communication training in the past 6 months
* had an HPV initiation rate greater than 72$
* had fewer than 49 patients aged 9-12
* had 1 or fewer HPV vaccine providers

Children's medical records will not be eligible to be included in the dataset if children:

* are not between the ages of 9-12 years at baseline
* are not attributed to a participating clinic at 12- or 24-month follow-up

Where this trial is running

Chapel Hill, North Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Human Papilloma Virusfinancial incentivespediatric medicinevaccinationpay-for-performance
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.