Improving HIV self-care for people who inject drugs

Stigma-Treatment Enhanced Incentivized Directly Observed Therapy for People With HIV Who Inject Drugs

Not applicable Interventional Massachusetts General Hospital · NCT05819411

This study is testing a new way to help people with HIV who inject drugs take better care of themselves by using a mobile app and therapy sessions to see if it makes a difference in their health.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment70 (estimated)
Ages18 Years and up
SexAll
SponsorMassachusetts General Hospital Academic / other
Locations1 site (Boston, Massachusetts)
Trial IDNCT05819411 on ClinicalTrials.gov

What this trial studies

This pilot randomized controlled trial aims to assess the feasibility and acceptability of an intervention designed to enhance HIV self-care among HIV-positive individuals who inject drugs and are not optimally engaged in HIV care. Participants will be randomly assigned to receive either a mobile application-facilitated directly observed therapy (iDOT) alone or iDOT combined with the iSTRIVE intervention, which includes therapy sessions focused on emotion regulation and communication skills. The study will take place at Fenway Health in Boston, MA, and participants will be compensated for their involvement and adherence to the protocol.

Who should consider this trial

Good fit: Ideal candidates for this study are HIV-positive individuals who inject drugs and have been sub-optimally engaged in HIV care.

Not a fit: Patients who are HIV-negative or who deny drug use in the past six months will not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve HIV self-care and engagement in treatment for individuals who inject drugs.

How similar studies have performed: Other studies have shown promise in using behavioral interventions to improve health outcomes in similar populations, suggesting potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* HIV positive
* HIV virally unsuppressed (\>20 copies/mL) in past year or no past-year HIV viral load result
* Drug use behavior endorsed in past 6 months
* Able to provide informed consent
* 18 years or older
* English speaking

Exclusion Criteria:

* HIV negative
* Denying drug use in past 6 months

Where this trial is running

Boston, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions HivSubstance Use Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.