Improving HIV prevention and substance use in homeless youth

Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness

Not applicable Interventional The University of Texas Health Science Center, Houston · NCT06074354

This study is testing a new program called MY-RIDE to see if it can help homeless youth reduce substance use and improve their HIV prevention efforts.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment450 (estimated)
Ages18 Years to 25 Years
SexAll
SponsorThe University of Texas Health Science Center, Houston Academic / other
Locations1 site (Houston, Texas)
Trial IDNCT06074354 on ClinicalTrials.gov

What this trial studies

This study evaluates the MY-RIDE intervention, which aims to reduce substance use and enhance HIV prevention strategies among youth experiencing homelessness. Participants will be divided into two groups: one receiving the MY-RIDE intervention and the other receiving attention control. The study will assess the impact of MY-RIDE on various factors, including willingness to take Pre-Exposure Prophylaxis (PrEP), stress levels, substance use urges, and access to mental health and substance use services over a 15-month period. The goal is to determine the effectiveness of this adaptive intervention in improving health outcomes for this vulnerable population.

Who should consider this trial

Good fit: Ideal candidates are youth experiencing homelessness who have engaged in substance use and are sexually active or plan to be.

Not a fit: Patients who are not experiencing homelessness or who have low literacy may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce HIV infections and substance use among homeless youth.

How similar studies have performed: Other studies have shown promise in using adaptive interventions for improving health outcomes in at-risk populations, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* have engaged in substance use (alcohol or illicit drugs)
* speak English
* are experiencing homelessness
* engaged in sexual activity in the last 6 months or plan to in the next month
* are not planning to move out of the metro area during the 15-month study period.

Exclusion Criteria:

* Youth Experiencing Homelessness (YEH) who have low literacy based on the Rapid Estimate of Adult Literacy in Medicine-Short Form (scores \< 4)

Where this trial is running

Houston, Texas

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions HIV Infections
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.