Improving HIV prevention and substance use in homeless youth
Official title: Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness
Run by The University of Texas Health Science Center, Houston · NCT06074354 · Data updated 2026-11-12
This study is testing a new program called MY-RIDE to see if it can help homeless youth reduce substance use and improve their HIV prevention efforts.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 25 Years |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | November 11, 2024 |
| Main results expected | August 23, 2027 |
| Study ends | August 23, 2027 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT06074354 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are youth experiencing homelessness who have engaged in substance use and are sexually active or plan to be.
✕Probably not a fit
Patients who are not experiencing homelessness or who have low literacy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the MY-RIDE intervention, which aims to reduce substance use and enhance HIV prevention strategies among youth experiencing homelessness. Participants will be divided into two groups: one receiving the MY-RIDE intervention and the other receiving attention control. The study will assess the impact of MY-RIDE on various factors, including willingness to take Pre-Exposure Prophylaxis (PrEP), stress levels, substance use urges, and access to mental health and substance use services over a 15-month period. The goal is to determine the effectiveness of this adaptive intervention in improving health outcomes for this vulnerable population.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce HIV infections and substance use among homeless youth.
How similar studies have gone: Other studies have shown promise in using adaptive interventions for improving health outcomes in at-risk populations, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * have engaged in substance use (alcohol or illicit drugs) * speak English * are experiencing homelessness * engaged in sexual activity in the last 6 months or plan to in the next month * are not planning to move out of the metro area during the 15-month study period. Exclusion Criteria: * Youth Experiencing Homelessness (YEH) who have low literacy based on the Rapid Estimate of Adult Literacy in Medicine-Short Form (scores \< 4)
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM — The University of Texas Health Science Center, Houston
- Study coordinator: Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM
- Email: Diane.M.SantaMaria@uth.tmc.edu
- Phone: 713-500-2002
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.