Improving fertilization rates and embryo quality in IVF patients using calcium ionophore
Improved the Low Fertilization Rates and Increased the High-quality Embryogenesis by Treatment with Calcium Ionophore GM508 CultActive Optimized Medium in Vitro Fertilization (IVF) Patients
This study is testing if a special treatment can help improve fertilization rates and embryo quality for IVF patients who have had trouble in the past, especially those over 40.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | Female |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT05722067 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the use of GM508 CultActive, a bicarbonate buffered reagent, to enhance fertilization rates and embryo development in IVF patients who have previously experienced poor fertilization or embryo quality. The study focuses on patients with a history of low fertilization rates, poor embryo development, or diminished ovarian reserve, particularly those over 40 years old. By treating oocytes with calcium ionophore, the researchers aim to improve outcomes for these challenging cases in assisted reproductive technology.
Who should consider this trial
Good fit: Ideal candidates for this study are IVF patients with a history of low fertilization rates, poor embryo quality, or diminished ovarian reserve, especially those over 40 years old.
Not a fit: Patients who have had no oocytes or only one oocyte retrieved will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly increase the chances of successful fertilization and embryo quality for patients undergoing IVF.
How similar studies have performed: While the specific use of calcium ionophore in this context may be novel, similar approaches in improving fertilization rates have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Low fertilization rate in previous IVF cycle (\<30%), or * Poor embryo developmental problems in previous IVF cycle, or * Diminished ovarian reserve (AMH\<1.2 or AFC\<5) and/or more than 40 y/o. Exclusion Criteria: * Without or just one oocyte picked up
Where this trial is running
Kaohsiung
- Chang Gung Memorial Hospital — Kaohsiung, Taiwan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.