Improving diagnosis of heart attacks using a new troponin test
SuperTROPO (Better Diagnostics of Myocardial Infarction With a Test for Special Forms of Troponin)
This study is testing a new troponin test to see if it can better identify heart attacks in emergency department patients compared to standard tests.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 19 Years to 110 Years |
| Sex | All |
| Sponsor | Turku University Hospital Government |
| Locations | 1 site (Turku) |
| Trial ID | NCT05858112 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enhance the diagnosis of myocardial infarction in emergency department patients by utilizing a novel assay called SuperTROPO to measure long forms of cardiac troponin T (cTnT). The study will assess whether the ratio of long cTnT to standard high-sensitivity cTnT can effectively differentiate type 1 NSTEMI patients from those with other causes of elevated cTnT levels. Additionally, it will compare long cTnT levels across various clinical groups and establish optimal cut-off values for diagnosis. The study will involve patients who have undergone routine troponin testing upon arrival at the emergency department.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who present to the emergency department with elevated high-sensitivity cTnT levels and have provided informed consent.
Not a fit: Patients who are unable to give informed consent, are legally incompetent, pregnant, or have previously participated in this study may not benefit.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of myocardial infarction, improving patient outcomes.
How similar studies have performed: While this approach is innovative, it builds on existing research into troponin testing, and similar studies have shown promise in improving diagnostic accuracy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient has arrived at the emergency department and high-sensitivity cTnT test (P-TnT) has been ordered as part of the routine "cardiac package" of laboratory tests upon arrival * Result of \>14 ng/L of the P-TnT test included in the "cardiac package" * Age \> 18 * The patient or his/her legal representative has given written informed consent for participation in the study Exclusion Criteria: * unable to give informed consent * legally incompetent individuals * pregnancy * previously participated in this study
Where this trial is running
Turku
- Turku University Hospital — Turku, Finland (Recruiting)
Study contacts
- Study coordinator: Konsta Teppo
- Email: jkitep@utu.fi
- Phone: 00358415027333
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.