Improving diagnosis of children with brain injuries and disorders of consciousness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the clinical evolution of children with severe acquired brain injury (ABI) and disorders of consciousness (DoC) by utilizing traditional behavioral scales such as the Coma Recovery Scale Revised (CRS-R) and the Coma Recovery Scale for Pediatrics (CRS-P). It aims to identify clinical markers of emergency (E-Markers) that indicate consciousness, which could enhance diagnostic accuracy when combined with existing scales. Special attention will be given to children under 12 months, focusing on developmental stages and motor abilities. The study seeks to address the high risk of misdiagnosis in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* suffering from an ABI due to: traumatic brain injury, hypoxic events/anoxia, cerebral infections, cerebrovascular accident;
* age: 2 months-25.11 years;
* having a Glasgow Coma Scale (GCS; Teasdale \& Jennett, 1974) at injury or onset ≤8);
* being in vegetative state (VS) or minimally conscious state (MCS) at admission;
* being in subacute or chronic phase.

Exclusion Criteria:

\- ABI due to brain tumor or neurodegenerative disease.

Where it's running

• Scientific Institute, IRCCS E. Medea
  Bosisio Parini, Lecco, Italy Recruiting

Study contacts

• Study coordinator: Sandra Strazzer, MD
• Email: sandra.strazzer@lanostrafamiglia.it
• Phone: +39031877111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.