Improving care for patients with acute respiratory distress syndrome in the ICU

ReLatIonship BEtween Implementation of Evidence-based and suppoRtive ICU cAre and ouTcomes of patIents With Acute respiratOry Distress syNdrome

This study looks at how following specific care guidelines and providing better nutrition can help improve the health and quality of life for patients with acute respiratory distress syndrome in the ICU.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 16 Years and up
• Sex: All
• Sponsor: Japanese Society for Early Mobilization (Academic / other)
• Locations: 1 site (Tokyo)
• Trial ID: NCT05844579 on ClinicalTrials.gov

What this trial studies

This observational study focuses on patients diagnosed with acute respiratory distress syndrome (ARDS) who are admitted to the ICU. It aims to evaluate the implementation of evidence-based guidelines and care strategies, including the ABCDEF bundles and nutritional therapy, to enhance patient outcomes and quality of life. The study will collect data on treatment compliance and the long-term effects of ICU care on survivors, particularly regarding their functional impairments and overall well-being. By analyzing these factors, the study seeks to inform better practices in ICU settings worldwide.

Who should consider this trial

Good fit: Ideal candidates for this study are patients aged 16 and older who are diagnosed with ARDS and require invasive or non-invasive ventilation within 24 hours of ICU admission.

Not a fit: Patients with terminal conditions or those who refuse to have their clinical data used in research may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved quality of life and functional recovery for ARDS patients after ICU discharge.

How similar studies have performed: Other studies have shown success with similar approaches in improving ICU care and patient outcomes, indicating that this methodology is supported by existing evidence.

Eligibility criteria

Inclusion Criteria:

1. Patients on an invasive or non-invasive ventilator within 24 hours of ICU admission
2. Patients who are expected to be on an invasive and/or non-invasive ventilator for more than 48 hours in total
3. Patients who meet the diagnosis of ARDS within 24 hours of ICU admission

Exclusion Criteria:

1. Patients who are younger than 16 years old
2. Patients with terminal conditions at the time of ICU admission
3. Patients who have been admitted to the ICU with a terminal care policy or who are expected to be admitted to the ICU with a terminal care policy within 24 hours of admission to the ICU
4. Patients who have expressed their refusal to have their clinical data used in research.

Where this trial is running

Tokyo

• LIBERATION Study Research Office — Tokyo, Japan (Recruiting)

Study contacts

• Study coordinator: Kensuke Nakamura, MD, PhD

Conditions Acute Respiratory Distress Syndrome; Post Intensive Care Syndrome; Treatment Compliance; Quality of Life