Improving cancer detection with advanced PET/CT imaging techniques
A Prospective Study of the Augmented Whole-body Scanning Via Magnifying PET/CT (AWSM-PET/CT) Techniques Abilities to Improve Upon the Diagnostic Accuracy of the Standard-of-care (SOC) PET/CT for Malignant Lesion Detection
NA · Washington University School of Medicine · NCT05513027
This study is testing a new imaging technique called AWSM-PET to see if it can help doctors find smaller cancer spots that regular PET/CT scans might miss.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 35 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Washington University School of Medicine (other) |
| Locations | 1 site (Saint Louis, Missouri) |
| Trial ID | NCT05513027 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of Augmented Whole-body Scanning via Magnifying PET (AWSM-PET) technology in enhancing the diagnostic accuracy of standard PET/CT imaging for cancer detection. The focus is on improving image resolution and sensitivity, particularly for detecting smaller malignant lesions that are often missed by conventional methods. Participants will undergo AWSM-PET imaging alongside standard PET/CT scans to compare the outcomes. The study aims to enroll adult patients with suspected or confirmed cancer who are scheduled for standard PET/CT imaging.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with suspected or confirmed carcinoma who are scheduled for standard PET/CT imaging.
Not a fit: Patients with conditions that preclude them from undergoing PET imaging or those not diagnosed with cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this technology could lead to earlier and more accurate detection of cancer, improving patient outcomes.
How similar studies have performed: While advancements in PET imaging have been made, this specific approach using AWSM-PET is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient 18 years of age or older * Patient with suspected or pathologically confirmed diagnosis of carcinoma scheduled to undergo standard of care (SOC) PET/CT for initial diagnosis, initial staging, or suspected recurrence. Preference is to enroll those subjects who will undergo biopsy or surgical resection prior to other cancer treatment. * Willing to undergo PET/CT imaging with AWSM-PET. * Patients of child-bearing potential must have a negative urine pregnancy test on the day of the PET/CT scan. Postmenopausal women who self-report as amenorrheic for at least 12 consecutive months are to be considered not of child-bearing potential. * Patients must be able to understand and sign an IRB-approved informed consent form that allows access to prior medical records, participation in the study and chart review follow up. * Patients are able to tolerate up to approximately 30 min of PET imaging. Exclusion Criteria: * For FDG PET/CT only: Patients who have poorly controlled diabetes (fasting blood glucose \> 200 mg/dL obtained directly prior to FDG administration for PET/CT scan) * Patients whose weight or whose body habitus prohibits the AWSM-PET insert device from being placed at the end of the imaging field of view
Where this trial is running
Saint Louis, Missouri
- Washington University School of Medicine — Saint Louis, Missouri, United States (RECRUITING)
Study contacts
- Principal investigator: Yuan-Chuan Tai, Ph.D. — Washington University School of Medicine
- Study coordinator: Yuan-Chuan Tai, Ph.D.
- Email: taiy@wustl.edu
- Phone: 314-362-8429
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cancer, Magnifying PET, virtual-pinhole PET, cancer, FDG PET/CT