Improving blood pressure medication adherence for people living with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to address the barriers that people living with HIV (PWH) face in adhering to antihypertensive medications after achieving viral suppression. It is structured into five aims, focusing on identifying patient-level factors, evaluating provider practices, and adapting healthcare delivery interventions to enhance medication adherence. The study will also assess the feasibility and acceptability of these interventions over a 24-week period. By targeting hypertension management in PWH, the study seeks to improve overall cardiovascular health outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aims 1A and 1B

* Age ≥18 years
* Confirmed HIV+ diagnosis
* Undetectable HIV viral load: defined as the most recent HIV viral load \<200 copies/mL checked within the past year (assessed via chart abstraction)
* Hypertension diagnosis in medical records
* Taking an antihypertensive medication
* Receiving care at the Duke HIV clinic

Aim 2

* HIV providers including infectious disease physicians, internists or advance practice practitioners who have a patient pool of PLWH under their care in the last 6 months.

Aim 3A

* Stakeholders composed of willing participants recruited from the Duke ID clinic and may include, HIV providers, clinic directors, nurses, pharmacists, social workers, people living with HIV who have hypertension and take antihypertensive medications, and representatives of the community advisory boards, and any other key stakeholders.

Aim 3 B

* Age ≥18 years
* Confirmed HIV+ diagnosis
* Receiving care at the Duke ID clinic
* Achievement of HIV suppression defined as having HIV-1 RNA \<200 copies/ml
* Take antihypertensive medications
* Uncontrolled BP over a 12 months period defined by participants with systolic BP\>130mmHg on ≥ 2 occasions in the past 12 months as indicated in the individual patient's electronic medical records

Exclusion Criteria:

Aims 1A, 1B and 3B

* Severely hearing or speech impaired, or other disability that would limit participation in the intervention components
* In a nursing home and/or receiving in-patient psychiatric care
* Terminal illness with life expectancy \< 4 months
* No reliable access to a telephone
* Pregnant, breast-feeding, or planning a pregnancy during the study period
* Planning to move out of the area in the next 6 months
* Non-English speaking.

Where it's running

• Duke University
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Charles Muiruri, PhD — Duke University
• Study coordinator: Stuart T Carr, BA
• Email: stuart.carr@duke.edu
• Phone: 919 668-4849

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.