Improving blood pressure medication adherence for people living with HIV
Addressing Barriers to Anti-hypertensive Medication Adherence Among Persons Living With HIV Who Have Achieved Viral Suppression
This study is testing ways to help people living with HIV stick to their blood pressure medications better after their viral load is under control.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Duke University Academic / other |
| Locations | 1 site (Durham, North Carolina) |
| Trial ID | NCT05459077 on ClinicalTrials.gov |
What this trial studies
This study aims to address the barriers that people living with HIV (PWH) face in adhering to antihypertensive medications after achieving viral suppression. It is structured into five aims, focusing on identifying patient-level factors, evaluating provider practices, and adapting healthcare delivery interventions to enhance medication adherence. The study will also assess the feasibility and acceptability of these interventions over a 24-week period. By targeting hypertension management in PWH, the study seeks to improve overall cardiovascular health outcomes.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a confirmed HIV diagnosis, undetectable viral load, and a diagnosis of hypertension who are receiving care at the Duke HIV clinic.
Not a fit: Patients who do not have hypertension or are not receiving care at the Duke HIV clinic may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better blood pressure control and reduced cardiovascular disease risk for patients living with HIV.
How similar studies have performed: While there has been limited research specifically targeting antihypertensive medication adherence in PWH, studies addressing medication adherence in chronic conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Aims 1A and 1B * Age ≥18 years * Confirmed HIV+ diagnosis * Undetectable HIV viral load: defined as the most recent HIV viral load \<200 copies/mL checked within the past year (assessed via chart abstraction) * Hypertension diagnosis in medical records * Taking an antihypertensive medication * Receiving care at the Duke HIV clinic Aim 2 * HIV providers including infectious disease physicians, internists or advance practice practitioners who have a patient pool of PLWH under their care in the last 6 months. Aim 3A * Stakeholders composed of willing participants recruited from the Duke ID clinic and may include, HIV providers, clinic directors, nurses, pharmacists, social workers, people living with HIV who have hypertension and take antihypertensive medications, and representatives of the community advisory boards, and any other key stakeholders. Aim 3 B * Age ≥18 years * Confirmed HIV+ diagnosis * Receiving care at the Duke ID clinic * Achievement of HIV suppression defined as having HIV-1 RNA \<200 copies/ml * Take antihypertensive medications * Uncontrolled BP over a 12 months period defined by participants with systolic BP\>130mmHg on ≥ 2 occasions in the past 12 months as indicated in the individual patient's electronic medical records Exclusion Criteria: Aims 1A, 1B and 3B * Severely hearing or speech impaired, or other disability that would limit participation in the intervention components * In a nursing home and/or receiving in-patient psychiatric care * Terminal illness with life expectancy \< 4 months * No reliable access to a telephone * Pregnant, breast-feeding, or planning a pregnancy during the study period * Planning to move out of the area in the next 6 months * Non-English speaking.
Where this trial is running
Durham, North Carolina
- Duke University — Durham, North Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Charles Muiruri, PhD — Duke University
- Study coordinator: Stuart T Carr, BA
- Email: stuart.carr@duke.edu
- Phone: 919 668-4849
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.