Clinical trial Recruiting at 1 site Observational Ages 18 and up

Improving blood management for patients undergoing heart surgery

Official title: Patient Blood Management in Cardiac Surgical Patients: the ICARUS-2 Study

Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06637137 · Data updated 2026-11-12

This study is testing if giving patients iron before heart surgery can help them recover better and need fewer blood transfusions.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment464 (estimated)
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Academic / other
Locations1 site (Roma)
StatusRecruiting
StartedFebruary 24, 2025
Main results expectedFebruary 28, 2027
Study endsFebruary 28, 2027
Registry record updatedSeptember 10, 2026
Trial IDNCT06637137 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult patients scheduled for elective cardiac surgery who do not have contraindications such as pregnancy or dialysis.

Probably not a fit

Patients who are pregnant, on dialysis, or refuse participation may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect data on patients scheduled for elective cardiac surgery to optimize hemoglobin levels and reduce the need for blood transfusions. A team of hematologists, along with cardiac anesthetists and surgeons, will evaluate patients' blood tests and address iron deficiency prior to surgery. The study builds on previous findings that intravenous iron supplementation can decrease post-operative transfusions and hospital stays. By correcting iron deficiency at least two weeks before surgery, the study seeks to enhance patient recovery and clinical outcomes.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the need for blood transfusions and improve recovery times for cardiac surgery patients.

How similar studies have gone: Previous studies have shown success with similar approaches, indicating that early iron supplementation can lead to better outcomes in cardiac surgery patients.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- all adult patients scheduled for elective cardiac surgery

Exclusion Criteria:

* pregnancy
* dyalisis
* patient's refusal

Where it's running

  • Fondazione Policlinico Gemelli IRCCS
    Roma, Italy
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.