Improving blood management for patients undergoing heart surgery
Official title: Patient Blood Management in Cardiac Surgical Patients: the ICARUS-2 Study
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06637137 · Data updated 2026-11-12
This study is testing if giving patients iron before heart surgery can help them recover better and need fewer blood transfusions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 464 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Status | Recruiting |
| Started | February 24, 2025 |
| Main results expected | February 28, 2027 |
| Study ends | February 28, 2027 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT06637137 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients scheduled for elective cardiac surgery who do not have contraindications such as pregnancy or dialysis.
✕Probably not a fit
Patients who are pregnant, on dialysis, or refuse participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to collect data on patients scheduled for elective cardiac surgery to optimize hemoglobin levels and reduce the need for blood transfusions. A team of hematologists, along with cardiac anesthetists and surgeons, will evaluate patients' blood tests and address iron deficiency prior to surgery. The study builds on previous findings that intravenous iron supplementation can decrease post-operative transfusions and hospital stays. By correcting iron deficiency at least two weeks before surgery, the study seeks to enhance patient recovery and clinical outcomes.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the need for blood transfusions and improve recovery times for cardiac surgery patients.
How similar studies have gone: Previous studies have shown success with similar approaches, indicating that early iron supplementation can lead to better outcomes in cardiac surgery patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- all adult patients scheduled for elective cardiac surgery Exclusion Criteria: * pregnancy * dyalisis * patient's refusal
Where it's running
-
Fondazione Policlinico Gemelli IRCCS
Roma, Italy Recruiting
Study contacts
- Study coordinator: filippo Corsi, MD
- Email: filippo.corsi@policlinicogemelli.it
- Phone: +390630151
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.