Improving addiction treatment decision-making for opioid use disorder
Adaptive Decision Support for Addiction Treatment (ADAPT) Factorial Trial
This study is testing a new system to help emergency department staff make better decisions about treating people with opioid use disorder to see if it leads to more patients getting the right care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1088 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Yale University Academic / other |
| Locations | 3 sites (Guilford, Connecticut and 2 other locations) |
| Trial ID | NCT06793696 on ClinicalTrials.gov |
What this trial studies
This project focuses on refining and optimizing a clinical decision support system called EMBED to enhance the treatment of opioid use disorder in emergency departments. Utilizing a Multiphase Optimization Strategy (MOST), the study will implement a factorial trial to test various strategies, including nurse prompts for withdrawal assessment and clinician prompts to encourage the use of the decision support system. The goal is to increase adherence to standard care protocols for administering buprenorphine to eligible patients. This is the first stage of a larger study that will include further optimization and evaluation phases.
Who should consider this trial
Good fit: Ideal candidates for this study are emergency department patients aged 18 and older with moderate to severe opioid use disorder.
Not a fit: Patients who are under 18 years of age, pregnant, or currently receiving medication for opioid use disorder may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for patients with opioid use disorder by ensuring they receive timely and appropriate care.
How similar studies have performed: Other studies have shown promise in using clinical decision support systems for addiction treatment, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Emergency department patient * 18 years of age or older * Moderate to severe opioid use disorder Exclusion Criteria: * Under 18 years of age * Pregnant * Currently receiving medication for opioid use disorder
Where this trial is running
Guilford, Connecticut and 2 other locations
- Yale New Haven Shoreline Medical Center — Guilford, Connecticut, United States (Recruiting)
- Yale New Haven Hospital- St. Raphael — New Haven, Connecticut, United States (Recruiting)
- Yale New Haven Hospital — New Haven, Connecticut, United States (Recruiting)
Study contacts
- Principal investigator: Edward Melnick, MD, MHS — Yale University
- Study coordinator: Edward Melnick, MD, MHS
- Email: edward.melnick@yale.edu
- Phone: 203-785-4363
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.