Impact of stress and exercise on glioblastoma treatment outcomes
Effect of StRess and ExeRcize on the Outcome After Chemo-Radiation
Maastricht Radiation Oncology · NCT05431348
This study looks at how stress affects treatment results for people with glioblastoma and whether exercise and sleep can help reduce that stress.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Maastricht Radiation Oncology (other) |
| Locations | 1 site (Maastricht, Limburg) |
| Trial ID | NCT05431348 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of psychological stress on the outcomes of patients with glioblastoma undergoing chemoradiation. It employs various methods to measure stress, including physiological assessments, stress biomarkers, and questionnaires. The study aims to understand how stress influences treatment efficacy and explores the potential role of physical activity and sleep in mitigating stress. Ultimately, it seeks to identify high-stress patients to develop future interventions aimed at reducing stress during treatment.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with glioblastoma or similar high-grade astrocytomas who are undergoing chemoradiation and can use a smartwatch.
Not a fit: Patients under 18 years old or those without access to a smartphone will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes and quality of life for glioblastoma patients by addressing stress management.
How similar studies have performed: While the relationship between stress and treatment outcomes has been explored in other contexts, this specific approach focusing on glioblastoma and the integration of technology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients treated with Stupp or Elderly protocol: GBM WHO IV, astrocytoma WHO IV IDHmt, astrocytoma WHO II IDHwt (GBM-like). * willing to wear the smart watch during the treatment protocol Exclusion Criteria: * younger than 18 years * not in possession of a smart phone
Where this trial is running
Maastricht, Limburg
- Maastricht Radiation Oncology (Maastro) — Maastricht, Limburg, Netherlands (RECRUITING)
Study contacts
- Principal investigator: Karen Zegers, PhD — Maastro Clinic, The Netherlands
- Study coordinator: Karen Zegers, PhD
- Email: karen.zegers@maastro.nl
- Phone: 0884455666
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glioblastoma, stress, glioblastoma, survival, quality of life