Impact of Soybean Flour on Blood Sugar Levels
The Effect of the Inclusion of Soybean Flour on Glycemic Responses of Bread, Tortilla, and Arepa to Enhance Human Nutrition
This study is testing if adding soybean flour to common foods like bread and tortillas can help overweight and obese people manage their blood sugar levels better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 21 Years to 45 Years |
| Sex | All |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Champaign, Illinois) |
| Trial ID | NCT06280625 on ClinicalTrials.gov |
What this trial studies
This study investigates how incorporating soybean flour into staple foods like bread and tortillas affects glycemic responses and satiety in overweight and obese individuals. By replacing a portion of wheat flour with soy flour, the research aims to enhance protein content and reduce blood sugar spikes, potentially lowering the risk of diabetes. Participants will be assessed for their glycemic and insulin responses after consuming these modified foods. The findings could inform nutritional guidelines and food formulations in regions where these staples are prevalent.
Who should consider this trial
Good fit: Ideal candidates are males and females aged 21-45 with a BMI between 25 and 40, who are overweight or obese.
Not a fit: Patients with diabetes, severe obesity, or those with certain health conditions like gluten intolerance or inflammatory diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to healthier staple foods that help manage blood sugar levels and improve satiety for overweight and obese individuals.
How similar studies have performed: Previous studies have shown that dietary modifications, including the use of alternative flours, can positively impact glycemic responses, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female between 21-45 years of age * All races/ethnicities * Body mass Index (BMI) \> 25 kg/m2 and \<40 kg/m2 (i.e., overweight and obesity, excluding severe obesity) * Fat %: \> 30% for female or \> 20% for male Exclusion Criteria: * Currently smokes or quit smoking nicotine cigarettes, vapes or E-cigarettes for less than 6 months ago * Pregnant, breastfeeding, menopausal * Hemoglobin: \<11g/dl for female and \<13g/dl for male * Blood donation in the past 8 weeks * Gluten intolerance (Gluten allergy, wheat allergy, celiac disease), Soy intolerance or allergy * Presence of malabsorption syndrome * History of bariatric surgery * Presence of inflammatory intestinal disease, liver, or kidney disease * Diabetes (fasting glucose level \>126mg/dl or plasma glucose level 2h after glucose challenge \>200 mg/dl) or taking medicines to treat diabetes * Polycystic ovary syndrome (pcos) * Untreated hypertension * Taking any medication that might affect glucose metabolism or the results of our study * History of cancer \<5 years ago * Abnormalities in the metabolic panel test (e.g., liver enzymes \>2 times the upper limit). * Seizures
Where this trial is running
Champaign, Illinois
- University of Illinois at Urbana Champaign — Champaign, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Marta Y Pepino de Gruev, PhD — University of Illinois at Urbana-Champaign
- Study coordinator: Stephanie Okoye, PharmD
- Email: siokoye2@illinois.edu
- Phone: 2173004709
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.