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Impact of social and genetic factors on young cancer survivors

Social Genomic Mechanisms of Health Disparities Among Adolescent and Young Adult (AYA) Survivors of Hodgkin and Non-Hodgkin Lymphoma

Observational Eastern Cooperative Oncology Group · NCT06002828

This study looks at how social and genetic factors affect the health and quality of life of young cancer survivors to see what challenges they face and how it impacts their long-term well-being.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages18 Years and up
SexAll
SponsorEastern Cooperative Oncology Group Research network
Drugs / interventionschemotherapy, radiation
Locations428 sites (Anchorage, Alaska and 427 other locations)
Trial IDNCT06002828 on ClinicalTrials.gov

What this trial studies

This observational study investigates how social and genetic factors influence the health outcomes of adolescent and young adult (AYA) survivors of Hodgkin and non-Hodgkin lymphoma. It aims to establish associations between social-environmental risk factors, individual resilience, and both disease-free and overall survival rates. Participants will complete questionnaires regarding their quality of life and provide blood samples at multiple time points over two years. The study seeks to better understand the unique challenges faced by AYA cancer survivors and how these factors may affect their long-term health.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 18-39 who were diagnosed with Hodgkin or non-Hodgkin lymphoma between the ages of 15-39 and have completed their cancer treatment.

Not a fit: Patients who are not English-speaking or those who have not completed their cancer treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for monitoring and supporting the health of adolescent and young adult cancer survivors.

How similar studies have performed: Other studies have shown success in exploring the impact of social and genetic factors on cancer outcomes, making this approach both relevant and potentially impactful.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patient must be \>= 18 years of age at the time of registration
* Patient must have been between the ages of 15-39 at the time of their first primary cancer diagnosis of Hodgkin lymphoma or non-Hodgkin lymphoma (NHL)
* Patient must have completed therapy (with a complete response, per clinician determination) at the time of registration
* Patients last date of prior systemic therapy for first primary diagnosis for Hodgkin lymphoma or non-Hodgkin lymphoma must have been within one year prior to registration

  * NOTE: Systemic therapy refers to all anti-cancer therapy, including but not limited to chemotherapy, intravenous (IV) or oral targeted medications, or radiation, and administered via a clinical trial or standard approach
* Patient must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-3
* Patient must be English speaking in order to be able to complete the required QOL forms on this study

  * NOTE: Sites cannot translate the associated QOL forms
* Patient must not be receiving active therapy for Hodgkin lymphoma or non-Hodgkin lymphoma
* Patient must have internet access through computer, tablet, or smartphone
* Patient must have email address
* Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible

Where this trial is running

Anchorage, Alaska and 427 other locations

+378 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Hodgkin LymphomaNon-Hodgkin Lymphoma
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.